SynthesisNature genetics2013
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
Open access · bronzeAbstract readComparative StudyMeta-Analysis
In one paragraph
Synthesis in Nature genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 493 papers, 15 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
493citing papers in PubMed, 15 pooled it
23.0field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
493 citing papers in PubMed, 15 syntheses or guidelines pooled it, 868 citations in OpenAlex.
- The janus-faced role of uric acid in COPD: evidence from East Asians population.NPJ primary care respiratory medicine · 2026Pooled it
- Integrated multi-omics mapping of the causal landscape of gout across the circulating-tissue axis.Frontiers in immunology · 2026Pooled it
- Genetic susceptibility to uric acid and selected cardiovascular outcomes: a systematic review and meta-analysis of Mendelian randomization studies.Frontiers in endocrinology · 2026Pooled it
- The association between genetic polymorphisms in GCKR and gout: A systematic review and meta-analysis.Medicine · 2025Pooled it
- Comprehensive Analysis of Uric Acid and Myasthenia Gravis: IGF1R as a Protective Factor and Potential Therapeutic Target.CNS neuroscience & therapeutics · 2025Pooled it
- Large-scale cross-ancestry genome-wide meta-analysis of serum urate.Nature communications · 2024Pooled it
- Serum uric acid and prognosis of ischemic stroke: Cohort study, meta-analysis and Mendelian randomization study.European stroke journal · 2024Pooled it
- Shared genetic correlations between kidney diseases and sepsis.Frontiers in endocrinology · 2024Pooled it
- Cross-phenotype association analysis of gastric cancer: in-silico functional annotation based on the disease-gene network.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2023Pooled it
- Uric acid and risk of pre-eclampsia: results from a large case-control study and meta-analysis of prospective studies.Scientific reports · 2023Pooled it
- Serum uric acid is not associated with major depressive disorder in European and South American populations: a meta-analysis and two-sample bidirectional Mendelian Randomization study.European journal of clinical nutrition · 2022Pooled it
- Novel Insights into the Effects of Genetic Variants on Serum Urate Response to an Acute Fructose Challenge: A Pilot Study.Nutrients · 2022Pooled it
- Genome-wide meta-analysis revealed several genetic loci associated with serum uric acid levels in Korean population: an analysis of Korea Biobank data.Journal of human genetics · 2022Pooled it
- Both variants of A1CF and BAZ1B genes are associated with gout susceptibility: a replication study and meta-analysis in a Japanese population.Human cell · 2021Pooled it
- Urate, Blood Pressure, and Cardiovascular Disease: Evidence From Mendelian Randomization and Meta-Analysis of Clinical Trials.Hypertension (Dallas, Tex. : 1979) · 2021Pooled it
- A potential association of SLC2A9 variant rs7442295 with uric acid at baseline and in interaction with iloperidone.The pharmacogenomics journal · 2026Trial
- Gene-environment interaction modifies the association between hyperinsulinemia and serum urate levels through SLC22A12.The Journal of clinical investigation · 2025Trial
- Oxypurinol pharmacokinetics and pharmacodynamics in healthy volunteers: Influence of BCRP Q141K polymorphism and patient characteristics.Clinical and translational science · 2021Trial
- Article
- ABCG2 transporter: Structural and functional associations with gout (Review).International journal of molecular medicine · 2026Review
433 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
230 authors at 20 institutions in 15 countries.
Anna KöttgenRenal Division, Freiburg University Hospital, Freiburg, Germany. anna.koettgen@uniklinik-freiburg.de
Eva Albrecht
Alexander Teumer
Veronique Vitart
Jan Krumsiek
Claudia Hundertmark
Giorgio Pistis
Daniela Ruggiero
Conall M O'Seaghdha
Toomas Haller
Qiong Yang
Toshiko Tanaka
Andrew D Johnson
Zoltán Kutalik
Albert V Smith
Julia Shi
Maksim Struchalin
Rita P S Middelberg
Morris J Brown
Angelo L Gaffo
Nicola Pirastu
Guo Li
Caroline Hayward
Tatijana Zemunik
Jennifer Huffman
Loic Yengo
Jing Hua Zhao
Ayse Demirkan
Mary F Feitosa
Xuan Liu
Giovanni Malerba
Lorna M Lopez
Pim van der Harst
Xinzhong Li
Marcus E Kleber
Andrew A Hicks
Ilja M Nolte
Asa Johansson
Federico Murgia
Sarah H Wild
Stephan J L Bakker
John F Peden
Abbas Dehghan
Maristella Steri
Albert Tenesa
Vasiliki Lagou
Perttu Salo
Massimo Mangino
Lynda M Rose
Terho Lehtimäki
Owen M Woodward
Yukinori Okada
Adrienne Tin
Christian Müller
Christopher Oldmeadow
Margus Putku
Darina Czamara
Peter Kraft
Laura Frogheri
Gian Andri Thun
Anne Grotevendt
Gauti Kjartan Gislason
Tamara B Harris
Lenore J Launer
Patrick McArdle
Alan R Shuldiner
Eric Boerwinkle
Josef Coresh
Helena Schmidt
Michael Schallert
Nicholas G Martin
Grant W Montgomery
Michiaki Kubo
Yusuke Nakamura
Toshihiro Tanaka
Patricia B Munroe
Nilesh J Samani
David R Jacobs
Kiang Liu
Pio D'Adamo
Sheila Ulivi
Jerome I Rotter
Bruce M Psaty
Peter Vollenweider
Gerard Waeber
Susan Campbell
Olivier Devuyst
Pau Navarro
Ivana Kolcic
Nicholas Hastie
Beverley Balkau
Philippe Froguel
Tõnu Esko
Andres Salumets
Kay Tee Khaw
Claudia Langenberg
Nicholas J Wareham
Aaron Isaacs
Aldi Kraja
Qunyuan Zhang
Philipp S Wild
Rodney J Scott
Elizabeth G Holliday
Elin Org
Margus Viigimaa
Stefania Bandinelli
Jeffrey E Metter
Antonio Lupo
Elisabetta Trabetti
Rossella Sorice
Angela Döring
Eva Lattka
Konstantin Strauch
Fabian Theis
Melanie Waldenberger
H-Erich Wichmann
Gail Davies
Alan J Gow
Marcel Bruinenberg
LifeLines Cohort Study
Ronald P Stolk
Jaspal S Kooner
Weihua Zhang
Bernhard R Winkelmann
Bernhard O Boehm
Susanne Lucae
Brenda W Penninx
Johannes H Smit
Gary Curhan
Poorva Mudgal
Robert M Plenge
Laura Portas
Ivana Persico
Mirna Kirin
James F Wilson
Irene Mateo Leach
Wiek H van Gilst
Anuj Goel
Halit Ongen
Albert Hofman
Fernando Rivadeneira
Andre G Uitterlinden
Medea Imboden
Arnold von Eckardstein
Francesco Cucca
Ramaiah Nagaraja
Maria Grazia Piras
Matthias Nauck
Claudia Schurmann
Kathrin Budde
Florian Ernst
Susan M Farrington
Evropi Theodoratou
Inga Prokopenko
Michael Stumvoll
Antti Jula
Markus Perola
Veikko Salomaa
So-Youn Shin
Tim D Spector
Cinzia Sala
Paul M Ridker
Mika Kähönen
Jorma Viikari
Christian Hengstenberg
Christopher P Nelson
CARDIoGRAM Consortium
DIAGRAM Consortium
ICBP Consortium
MAGIC Consortium
James F Meschia
Michael A Nalls
Pankaj Sharma
Andrew B Singleton
Naoyuki Kamatani
Tanja Zeller
Michel Burnier
John Attia
Maris Laan
Norman Klopp
Hans L Hillege
Stefan Kloiber
Hyon Choi
Mario Pirastu
Silvia Tore
Nicole M Probst-Hensch
Henry Völzke
Vilmundur Gudnason
Afshin Parsa
Reinhold Schmidt
John B Whitfield
Myriam Fornage
Paolo Gasparini
David S Siscovick
Ozren Polašek
Harry Campbell
Igor Rudan
Nabila Bouatia-Naji
Andres Metspalu
Ruth J F Loos
Cornelia M van Duijn
Ingrid B Borecki
Luigi Ferrucci
Giovanni Gambaro
Ian J Deary
Bruce H R Wolffenbuttel
John C Chambers
Winfried März
Peter P Pramstaller
Harold Snieder
Ulf Gyllensten
Alan F Wright
Gerjan Navis
Hugh Watkins
Jacqueline C M Witteman
Serena Sanna
Sabine Schipf
Malcolm G Dunlop
Anke Tönjes
Samuli Ripatti
Nicole Soranzo
Daniela Toniolo
Daniel I Chasman
Olli Raitakari
W H Linda Kao
Marina Ciullo
Caroline S Fox
Mark Caulfield
Murielle Bochud
Christian Gieger
University Medical Center Groningen · NLBrigham and Women's Hospital · USHelmholtz Zentrum München · DEInstitute of Genetics and Cancer · GBJohns Hopkins University · USAddenbrooke's Hospital · GBCentre for Human Genetics · GBUniversitätsmedizin Greifswald · DEUniversity of Maryland, Baltimore · USCentre National de la Recherche Scientifique · FRErasmus MC · NLSwiss Tropical and Public Health Institute · CHUniversity of Edinburgh · GBUniversity of Trieste · ITWashington University in St. Louis · USBoston University · USEurac Research · ITNational Heart Lung and Blood Institute · USNational Institutes of Health · USQIMR Berghofer Medical Research Institute · AU
Funding
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI GIOVANNUCCI, EDWARD · 2000 to 2019
$77.8MInstitute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4MWomen's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2MCardiovascular Genomics and Bioinformatics projectsZIAHL006170 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI JOHNSON, ANDREW · 2013 to 2025
$25.3MPharmacogenomics and Risk of Cardiovascular DiseaseU01HL069757 · NHLBI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI KRAUSS, RONALD M · 2001 to 2009
$24.7MA Center for GEI Association StudiesU01HG004424 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2007 to 2010
$21.4MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MZonulin Antibodies in Intestinal Permeabilitiy in IDDMM01RR016500 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI OSWALD, LYNN M · 2002 to 2009
$20.2MWORK DISABILITY-- PERSONS WITH RHEUMATOID ARTHRITISP60AR047785 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FELSON, DAVID TOBIN · 2001 to 2016
$18.0MResearch BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
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Abstract
Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4). Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional excretion of urate. Network analyses implicate the inhibins-activins signaling pathways and glucose metabolism in systemic urate control. New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout.
Indexed as
Analysis of VarianceGene FrequencyGenetic LociGenome-Wide Association StudyGlucoseGoutHumansInhibinsPolymorphism, Single NucleotideSignal TransductionUric AcidWhite PeopleGlucoseInhibinsUric Acid
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