ArticlePsychopharmacology2013
Effects of methamphetamine self-administration on actigraphy-based sleep parameters in rhesus monkeys.
Article in Psychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Naltrexone blocks the sleep-disrupting effects of methamphetamine in male rhesus monkeys.Drug and alcohol dependence · 2025Article
- Competitive roles of slow/delta oscillation-nesting-mediated sleep disruption under acute methamphetamine exposure in monkeys.Journal of Zhejiang University. Science. B · 2025Article
- Individuals recently abstinent from methamphetamine show selective cognitive and behavioral differences when compared to age-matched controls.Frontiers in psychiatry · 2025Article
- Methamphetamine and Designer Stimulants Modulate Tonic Human Cerebrovascular Smooth Muscle Contractility: Relevance to Drug-Induced Neurovascular Stress.Pathophysiology : the official journal of the International Society for Pathophysiology · 2023Article
- Transcranial Stimulation for the Treatment of Stimulant Use Disorder.Neurology international · 2023Review
- Tryptophan and Substance Abuse: Mechanisms and Impact.International journal of molecular sciences · 2023Review
- The dual orexin receptor antagonist almorexant blocks the sleep-disrupting and daytime stimulant effects of methamphetamine in rhesus monkeys.Drug and alcohol dependence · 2021Article
- Gibbon sleep quantified: the influence of lunar phase and meteorological variables on activity in Hylobates moloch and Hylobates pileatus.Primates; journal of primatology · 2021Article
- Enriched sleep environments lengthen lemur sleep duration.PloS one · 2021Article
- Potential use of actigraphy to measure sleep in monkeys: comparison with behavioral analysis from videography.Zoological research · 2020Article
- Eulerian videography technology improves classification of sleep architecture in primates.Primates; journal of primatology · 2019Article
- Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) and R(-) MDMA on actigraphy-based daytime activity and sleep parameters in rhesus monkeys.Experimental and clinical psychopharmacology · 2018Article
- GABANeuropharmacology · 2017Article
- Assessment of tolerance to the effects of methamphetamine on daytime and nighttime activity evaluated with actigraphy in rhesus monkeys.Psychopharmacology · 2017Article
- Effects of a Serotonin 2C Agonist and a 2A Antagonist on Actigraphy-Based Sleep Parameters Disrupted by Methamphetamine Self-Administration in Rhesus Monkeys.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Altered activity-based sleep measures in rhesus monkeys following cocaine self-administration and abstinence.Drug and alcohol dependence · 2016Article
- Actigraphy-based sleep parameters during the reinstatement of methamphetamine self-administration in rhesus monkeys.Experimental and clinical psychopharmacology · 2016Article
- Effects of quetiapine treatment on cocaine self-administration and behavioral indices of sleep in adult rhesus monkeys.Psychopharmacology · 2015Article
- The relationship between cocaine self-administration and actigraphy-based measures of sleep in adult rhesus monkeys.Psychopharmacology · 2013Article
- Reply to Dr. Kawada's letter.Psychopharmacology · 2013Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
rationaleSleep disorders and substance abuse are highly comorbid. Although methamphetamine is a very commonly abused drug, to the best of our knowledge, no study has evaluated its effects on sleep during drug use and abstinence under well-controlled conditions in laboratory animals.
objectivesThe objective of this study was to examine the effects of methamphetamine self-administration on sleep-like measures in nonhuman primates.
methodsAdult male rhesus monkeys (Macaca mulatta; n = 4) self-administered methamphetamine (0.01 and 0.03 mg/kg/injection, i.v.) under a fixed-ratio 20 schedule of reinforcement (60-min sessions once a day, 5 days per week) for 5 weeks. Sleep-like measures were evaluated with Actiwatch monitors before, during, and after each period of drug self-administration.
resultsBoth doses of methamphetamine reliably maintained self-administration. Methamphetamine (0.03 mg/kg) increased derived measures of latency to sleep onset and sleep fragmentation, and decreased sleep efficiency compared to abstinence, and higher methamphetamine intake predicted worse sleep quality. However, sleep normalized immediately after the discontinuation of methamphetamine self-administration.
conclusionsMethamphetamine markedly disrupted sleep-like measures; however, methamphetamine self-administration did not disrupt sleep quality during subsequent periods of drug abstinence.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.