Trial reportHuman genetics2013
Genetic association suggests that SMOC1 mediates between prenatal sex hormones and digit ratio.
Trial report in Human genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Probing the genomic landscape of human sexuality: a critical systematic review of the literature.Frontiers in genetics · 2023Pooled it
- Genome-wide association study identifies nine novel loci for 2D:4D finger ratio, a putative retrospective biomarker of testosterone exposure in utero.Human molecular genetics · 2018Pooled it
- Digit ratio (2D:4D), aggression, and testosterone in men exposed to an aggressive video stimulus.Evolutionary psychology : an international journal of evolutionary approaches to psychology and behavior · 2013Trial
- The methodological and ethical concerns of genetic studies of same-sex sexual behavior.American journal of human genetics · 2024Review
- Variations in gender identity and sexual orientation of university students.Sexual medicine · 2023Article
- Associations Between Cytochrome P450 (CYP) Gene Single-Nucleotide Polymorphisms and Second-to-Fourth Digit Ratio in Chinese University Students.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Second-to-fourth digit ratio and facial shape in Buryats of Southern Siberia.Early human development · 2020Article
- Oxytocin receptor gene polymorphism (rs53576) and digit ratio associates with aggression: comparison in seven ethnic groups.Journal of physiological anthropology · 2020Article
- Secreted modular calcium-binding proteins in pathophysiological processes and embryonic development.Chinese medical journal · 2019Review
- The 2nd to 4th digit length ratio (2D:4D) among children of Seveso women exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.Early human development · 2019Article
- Digit ratio predicts the number of lifetime recruits in female collared flycatchers.Biology letters · 2019Article
- Digit Ratio (2D:4D) Predicts Self-Reported Measures of General Competitiveness, but Not Behavior in Economic Experiments.Frontiers in behavioral neuroscience · 2017Article
- Genetic control of weight loss during pneumonic Burkholderia pseudomallei infection.Pathogens and disease · 2014Article
- No Evidence that 2D:4D is Related to the Number of CAG Repeats in the Androgen Receptor Gene.Frontiers in endocrinology · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Men and women differ statistically in the relative lengths of their index and ring fingers; and the ratio of these lengths has been used as a biomarker for prenatal testosterone. The ratio has been correlated with a wide range of traits and conditions including prostate cancer, obesity, autism, ADHD, and sexual orientation. In a genome-wide association study of 979 healthy adults, we find that digit ratio is strongly associated with variation upstream of SMOC1 (rs4902759: P = 1.41 × 10(-8)) and a meta-analysis of this and an independent study shows a probability of P = 1.5 × 10(-11). The protein encoded by SMOC1 has recently been shown to play a critical role in limb development; its expression in prostate tissue is dependent on sex hormones, and it has been implicated in the sexually dimorphic development of the gonads. We put forward the hypothesis that SMOC1 provides a link between prenatal hormone exposure and digit ratio.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.