Evidence map›Paper›PMID 23262977›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2013

Health care resource utilization in untreated HIV-infected children in a pediatric programme, Abidjan, Côte d'Ivoire, 2004-2009.

Sophie Desmonde, Patrick A Coffie, Edmond A Aka, Clarisse Amani-Bosse, Eugène Messou, François Dabis, Andrea Ciaranello, Valériane Leroy

Abstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Reasons for hospitalization in HIV-infected children in West Africa.Journal of the International AIDS Society · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sophie DesmondeCentre INSERM, U897-Epidémiologie-Biostatistiques, Bordeaux, France. sophie.desmonde@isped.u-bordeaux2.fr
Patrick A Coffie
Edmond A Aka
Clarisse Amani-Bosse
Eugène Messou
François Dabis
Andrea Ciaranello
Valériane Leroy

Funding

LOC-IMPAACT Leadership GroupPharmacokinetics and Safety of Remdesivir for Treatment of COVID-19 in Pregnant Women in the USUM1AI068632 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI Jennifer Jao, Sharon A Nachman · 2011 to 2026
$278.1M
WADA (West Africa Database on Antiretroviral Therapy) CollaborationU01AI069919 · NIAID · UNIVERSITY OF BORDEAUX II · PI Didier Koumavi Ekouevi, Antoine Jaquet · 2006 to 2026
$29.9M
Optimizing HIV Care in Less Developed CountriesR01AI058736 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Kenneth Alan Freedberg, Emily Parker Hyle · 2004 to 2026
$21.5M
Optimizing Outcomes for HIV-Exposed and HIV-Infected Children in South AfricaK01AI078754 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI CIARANELLO, ANDREA LYNNE · 2009 to 2013
$685k
ANALYSES OF THE S TYPYIMURIUM TYROSINE PHOSPHATASE SPTPF32AI009919 · NIAID · YALE UNIVERSITY · PI MURLI, SUMATI · 1997 to 1999
–
NIAID NIH HHS 5U01AI09919-01-05NIAID NIH HHS F32 AI009919NIAID NIH HHS K01 AI078754NIAID NIH HHS K01AI078754NIAID NIH HHS R01AI05873NIAID NIH HHS R01 AI058736NIAID NIH HHS U01 AI069919NIAID NIH HHS UM1 AI068632PHS HHS R01 A1058736
6 · The paper itself

Abstract

backgroundWe describe health care resource utilization among HIV-1-infected children who have not yet undergone antiretroviral treatment (ART) in Abidjan, Côte d'Ivoire.

methodsHIV-infected children enrolled prospectively in an HIV care programme in 2 health facilities in Abidjan (2004-2009) were followed up from date of inclusion until database closeout, death, ART initiation, or loss to follow-up (no clinical contact for more than 6 months). Incidences of health care resource utilization (outpatient care, inpatient day care, and hospitalization) were described according to severe morbidity and mixed effect log linear models were computed to identify associated factors.

resultsOverall, 405 children were included, entering care at a median age of 4.5 years, 66.9% were receiving cotrimoxazole prophylaxis, and 27.7% met 2006 WHO criteria for immunodeficiency by age. The median follow-up time was 11.6 months (interquartile range: 1.4; 30.7). Overall, 371 clinical events occurred in 162 children yielding to an incidence rate (IR) of 60.9/100 child-years (CY) [95% confidence interval (CI): 55.1 to 67.2]: 57% of clinical events led to outpatient care (IR: 33/100 CY), 38% to inpatient day care (IR: 22/100 CY), and 10% to hospitalization (IR: 5.9/100 CY). Further medical examinations were made allowing confirmed diagnoses in 40% of those (IR: 22.4/100 CY). Outpatient care was less common among immunodeficient children than those not (relative risk [RR] = 0.32, 95% CI: 0.18 to 0.56), in those whose main caregivers are both parents compared with those who are primarily cared for by their mother only (RR = 0.34, 95% CI: 0.15 to 0.77).

conclusionUntreated HIV-infected children require substantial inpatient and outpatient care in a context where ART is scaling up but still not available to all.

Indexed as

AdolescentAmbulatory CareChildChild, PreschoolCohort StudiesCote d'IvoireFemaleHealth ServicesHIV InfectionsHospitalizationHumansInfantInfant, NewbornMaleProspective Studies

Identifiers

PMID23262977
PMCPMC3568205

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.