ArticleObstetrics and gynecology2013
Prevalence, trends, and patterns of use of antidiabetic medications among pregnant women, 2001-2007.
Article in Obstetrics and gynecology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Cognitive function in metformin exposed children, born to mothers with PCOS - follow-up of an RCT.BMC pediatrics · 2020Trial
- The Clinical Pharmacokinetics and Pharmacodynamics of Glimepiride-A Systematic Review and Meta-Analysis.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Maternal and neonatal outcomes of antihypertensive treatment in pregnancy: A retrospective cohort study.PloS one · 2022Article
- Maternal sociodemographic characteristics, early pregnancy behaviours, and livebirth outcomes as congenital heart defects risk factors - Northern Ireland 2010-2014.BMC pregnancy and childbirth · 2021Article
- Trends and associated maternal characteristics of antidiabetic medication use among pregnant women in South Korea.Scientific reports · 2021Article
- Dutch trends in the use of potentially harmful medication during pregnancy.British journal of clinical pharmacology · 2020Article
- Use of Antidiabetic drugs during pregnancy among U.S. women with Livebirth deliveries in the Mini-Sentinel system.BMC pregnancy and childbirth · 2019Article
- Antidiabetic medication use during pregnancy: an international utilization study.BMJ open diabetes research & care · 2019Observational
- Approach to evaluating pregnancy safety of anti-rheumatic medications in the OTIS MotherToBaby pregnancy studies: what have we learned?Rheumatology (Oxford, England) · 2018Article
- Metformin exposure in first trimester of pregnancy and risk of all or specific congenital anomalies: exploratory case-control study.BMJ (Clinical research ed.) · 2018Article
- Chinese medicine as complementary therapy for female infertility.Chinese journal of integrative medicine · 2017Review
- Prescribing of Antidiabetic Medicines before, during and after Pregnancy: A Study in Seven European Regions.PloS one · 2016Article
- Medication exposure during pregnancy: a pilot pharmacovigilance system using health and demographic surveillance platform.BMC pregnancy and childbirth · 2014Observational
- Trends in glyburide compared with insulin use for gestational diabetes treatment in the United States, 2000-2011.Obstetrics and gynecology · 2014Article
- Perinatal outcomes in type 2 diabetes.Current diabetes reports · 2014Review
Corrections and comments
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Authors and funding
19 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo describe the prevalence, trends, and patterns in use of antidiabetic medications to treat hyperglycemia and insulin resistance before and during pregnancy in a large U.S. cohort of insured pregnant women.
methodsPregnancies resulting in live births were identified (N=437,950) from 2001 to 2007 among 372,543 females 12-50 years of age at delivery from 10 health maintenance organizations participating in the Medication Exposure in Pregnancy Risk Evaluation Program. Information for these descriptive analyses, including all antidiabetic medications dispensed during this period, was extracted from electronic health records and newborn birth certificates.
resultsA little more than 1% (1.21%) of deliveries were to women dispensed antidiabetic medication in the 120 days before pregnancy. Use of antidiabetic medications before pregnancy increased from 0.66% of deliveries in 2001 to 1.66% of deliveries in 2007 (P<.001) because of an increase in metformin use. Most women using metformin before pregnancy had a diagnosis code for polycystic ovaries or female infertility (67.2%), whereas only 13.6% had a diagnosis code for diabetes. The use of antidiabetic medications during the second or third trimester of pregnancy increased from 2.8% of deliveries in 2001 to 3.6% in 2007 (P<.001). Approximately two thirds (68%) of women using metformin before pregnancy did not use any antidiabetic medications during pregnancy.
conclusionsAntidiabetic medication use before and during pregnancy increased from 2001 to 2007, possibly because of increasing prevalence of gestational diabetes mellitus, type 1 and type 2 diabetes, and other conditions associated with insulin resistance. LEVEL OF EVIDENCE: III.
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