ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2013
Overexpression of histamine H₄ receptors in the kidney of diabetic rat.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Histamine regulates the activity and the expression of the NaInflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- Renal histaminergic system and acute effects of histamine receptor 2 blockade on renal damage in the Dahl salt-sensitive rat.American journal of physiology. Renal physiology · 2023Article
- Functional role of histamine receptors in the renal cortical collecting duct cells.American journal of physiology. Cell physiology · 2022Article
- The Interplay between Histamine HBiomolecules · 2021Article
- The implications of histamine metabolism and signaling in renal function.Physiological reports · 2021Review
- Enigmatic Histamine Receptor HLife (Basel, Switzerland) · 2020Review
- Histamine in the kidneys: what is its role in renal pathophysiology?British journal of pharmacology · 2020Review
- Effect of Bilastine on Diabetic Nephropathy in DBA2/J Mice.International journal of molecular sciences · 2019Article
- AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction.Physiological reports · 2019Article
- International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors.Pharmacological reviews · 2015Review
- H3 receptor renal expression in normal and diabetic rats.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015Article
- Histamine receptor expression in human renal tubules: a comparative pharmacological evaluation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
OBJECTIVE AND
designThe renal expression of H1 and H2 receptors has previously been demonstrated, while that of the H4 receptor has been poorly investigated, and thus the aim of this research was to investigate the expression of the H4 receptor in the kidney of diabetic rats. MATERIAL OR SUBJECTS: 24 8-week-old male Wistar rats. TREATMENT: Diabetes was induced in 12 rats by a single intravenous injection of streptozotocin, and animals were killed 6 weeks later.
methodsKidneys were collected and processed for quantitative PCR or immunohistochemical analyses. To ascertain the renal topology of the H4 receptor, colocalization experiments were performed with a series of markers.
resultsH4 receptor is expressed in healthy rats, although at a very low level, and is strongly upregulated in diabetic animals. Immunohistochemical analysis revealed the highest immune-positivity in the medulla. Colocalization experiments revealed a close overlap in expression topology of the H4 receptor and both Tamm-Horsfall glycoprotein and aquaporin 1 was observed.
conclusionsThe results demonstrate, for the first time, that the H4 receptor is expressed in the kidney mainly by resident renal cells of the loop of Henlé and that this receptor is significantly overexpressed in diabetic animals, thus suggesting a possible role in the pathogenesis of diabetes-associated renal disease.
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