ArticleProceedings of the National Academy of Sciences of the United States of America1990
The t(10;14)(q24;q11) of T-cell acute lymphoblastic leukemia juxtaposes the delta T-cell receptor with TCL3, a conserved and activated locus at 10q24.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 58 citations in OpenAlex.
- Oncogenic and tumor suppressor function of MEIS and associated factors.Turkish journal of biology = Turk biyoloji dergisi · 2020Article
- Genomic characterization of pediatric T-cell acute lymphoblastic leukemia reveals novel recurrent driver mutations.Oncotarget · 2016Article
- Review
- Article
- A model for spontaneous B-lineage lymphomas in IgHmu-HOX11 transgenic mice.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Optimal activation of an endogenous gene by HOX11 requires the NH2-terminal 50 amino acids.Molecular and cellular biology · 1998Article
- Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Molecular involvement of the pvt-1 locus in a gamma/delta T-cell leukemia bearing a variant t(8;14)(q24;q11) translocation.Molecular and cellular biology · 1992Article
- S1 nuclease hypersensitive sites in an oligopurine/oligopyrimidine DNA from the t(10;14) breakpoint cluster region.Nucleic acids research · 1992Article
- HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein.The EMBO journal · 1991Article
- New nucleotide sequence data on the EMBL File Server.Nucleic acids research · 1990Article
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Authors and funding
10 authors at 1 institution in 1 country.
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Abstract
We cloned the t(10;14) recurrent translocation from CD3-negative T-cell acute lymphoblastic leukemia cells. The breakpoint at 14q11 involved an intermediate rearrangement of the delta T-cell receptor locus, suggesting that the translocation arose at the time of antigen receptor assemblage. Translocation introduced chromosome segment 10q24 as proven by hybridization of a breakpoint-derived probe to flow-sorted chromosomes and metaphase chromosomes. Two t(10;14) breakpoints were clustered within a 600-base-pair region of 10q24 but no heptamer-spacer-nonamer motifs resembling T-cell receptor/immunoglobulin rearrangement signals were noted at the breakpoint. A locus distinct from terminal deoxynucleotidyltransferase was found at 10q24. Evolutionarily conserved regions surrounding the 10q24 breakpoint were examined for transcriptional activity. A region telomeric to the 10q24 breakpoint, expected to translocate to the der(14) chromosome, recognized an abundant 2.9-kilobase RNA in a t(10;14) T-cell leukemia. This locus was not active in a variety of other normal and neoplastic T cells, arguing that it was deregulated by the introduction of the T-cell receptor. This locus is a candidate for a putative protooncogene, TCL3, involved in T-cell neoplasia.
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