ArticleProceedings of the National Academy of Sciences of the United States of America1990
Hormonal regulation of potassium currents in single myometrial cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Mapping uterine calcium dynamics during the ovulatory cycle in live mice.bioRxiv : the preprint server for biology · 2024Article
- Mechanism of Relaxation Via TASK-2 Channels in Uterine Circular Muscle of Mouse.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2013Article
- The stretch-dependent potassium channel TREK-1 and its function in murine myometrium.The Journal of physiology · 2011Article
- Pregnancy switches adrenergic signal transduction in rat and human uterine myocytes as probed by BKCa channel activity.The Journal of physiology · 2000Article
- Changes in the mechanisms involved in uterine contractions during pregnancy in guinea-pigs.The Journal of physiology · 2000Article
- Voltage-gated K+ currents in freshly isolated myocytes of the pregnant human myometrium.The Journal of physiology · 1999Article
- Potassium currents in freshly dissociated uterine myocytes from nonpregnant and late-pregnant rats.The Journal of general physiology · 1998Article
- Sodium and calcium inward currents in freshly dissociated smooth myocytes of rat uterus.The Journal of general physiology · 1997Article
- Inhibition of minK protein induced K+ channels in Xenopus oocytes by estrogens.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- Effects of metabolic inhibition and changes of intracellular pH on potassium permeability and contraction of rat uterus.The Journal of physiology · 1993Article
- Electrophysiological properties of membrane currents in single myometrial cells isolated from pregnant rats.Pflugers Archiv : European journal of physiology · 1991Article
- GTP-dependent regulation of myometrial KCa channels incorporated into lipid bilayers.The Journal of general physiology · 1990Article
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3 authors.
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Abstract
Three potassium currents (IK) were recorded from myometrial cells isolated from the uterus of rats at estrus and diestrus and kept in culture for 1-6 days. IK were differentiated by their modulation with norepinephrine and/or by their onset kinetics. At +50 mV the activation time constants were about 0.7 ms, 6 ms, and 15 ms for the fast, the intermediate, and the slow IK, respectively. Norepinephrine (1 microM) potentiated the fast IK and reduced the intermediate IK. In addition, differences were found with respect to cells from animals at estrus and diestrus. The fast IK was preferentially expressed in cultures from animals at estrus, whereas the intermediate IK was more frequent in cells from rats at diestrus. These results indicate that K+ channels from myometrial cells are multiregulated. Regulation may occur by short-term signals (neurotransmitters) and/or by preferentially expressing distinct types of channels depending on the hormonal status of the animal.
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