ArticleNature structural & molecular biology2013
A pseudoatomic model of the COPII cage obtained from cryo-electron microscopy and mass spectrometry.
Article in Nature structural & molecular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 65 citations in OpenAlex.
- Review
- Development of a Thiol-ene Microfluidic Chip for Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS).Analytical chemistry · 2025Article
- The Sar1 GTPase is dispensable for COPII-dependent cargo export from the ER.Cell reports · 2023Article
- An interaction between β'-COP and the ArfGAP, Glo3, maintains post-Golgi cargo recycling.The Journal of cell biology · 2023Article
- Probing intracellular vesicle trafficking and membrane remodelling by cryo-EM.Journal of structural biology · 2022Review
- Structure of the complete, membrane-assembled COPII coat reveals a complex interaction network.Nature communications · 2021Article
- Combinatorial multivalent interactions drive cooperative assembly of the COPII coat.The Journal of cell biology · 2020Article
- Analyzing Ribosome Remodeling in Health and Disease.Proteomics · 2020Review
- Cargo crowding contributes to sorting stringency in COPII vesicles.The Journal of cell biology · 2020Article
- COPII-mediated trafficking at the ER/ERGIC interface.Traffic (Copenhagen, Denmark) · 2019Review
- Interlaboratory Comparison of Hydrogen-Deuterium Exchange Mass Spectrometry Measurements of the Fab Fragment of NISTmAb.Analytical chemistry · 2019Article
- Tracking Higher Order Protein Structure by Hydrogen-Deuterium Exchange Mass Spectrometry.Protein and peptide letters · 2019Review
- Pore timing: the evolutionary origins of the nucleus and nuclear pore complex.F1000Research · 2019Review
- Flexibility of the Sec13/31 cage is influenced by the Sec31 C-terminal disordered domain.Journal of structural biology · 2018Article
- COPII-dependent ER export in animal cells: adaptation and control for diverse cargo.Histochemistry and cell biology · 2018Review
- Membrane Transport at an Organelle Interface in the Early Secretory Pathway: Take Your Coat Off and Stay a While: Evolution of the metazoan early secretory pathway.BioEssays : news and reviews in molecular, cellular and developmental biology · 2018Review
- Image processing for cryogenic transmission electron microscopy of symmetry-mismatched complexes.Bioscience reports · 2018Article
- COPII-coated membranes function as transport carriers of intracellular procollagen I.The Journal of cell biology · 2017Article
- Mapping the contact surfaces in the Lamin A:AIMP3 complex by hydrogen/deuterium exchange FT-ICR mass spectrometry.PloS one · 2017Article
- TANGO1/cTAGE5 receptor as a polyvalent template for assembly of large COPII coats.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
COPII vesicles transport proteins from the endoplasmic reticulum to the Golgi apparatus. Previous COPII-cage cryo-EM structures lacked the resolution necessary to determine the residues of Sec13 and Sec31 that mediate assembly and flexibility of the COPII cage. Here we present a 12-Å structure of the human COPII cage, where the tertiary structure of Sec13 and Sec31 is clearly identifiable. We employ this structure and a homology model of the Sec13-Sec31 complex to create a reliable pseudoatomic model of the COPII cage. We combined this model with hydrogen/deuterium-exchange MS analysis to characterize four distinct contact regions at the vertices of the COPII cage. Furthermore, we found that the two-fold symmetry of the Sec31 dimeric region in Sec13-Sec31 is broken upon cage formation and that the resulting hinge is essential to form the proper edge geometry in COPII cages.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.