ArticleMolecular and cellular neurosciences2013
Glial cell line-derived neurotrophic factor (GDNF) induces neuritogenesis in the cochlear spiral ganglion via neural cell adhesion molecule (NCAM).
Article in Molecular and cellular neurosciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Enhanced nerve regeneration after transplantation of NCAM-positive neural crest-like cells derived from human iPSC.Inflammation and regeneration · 2026Article
- A Neuroelectronic Interface with Microstructured Substrates for Spiral Ganglion Neurons Cultured In Vitro: Proof of Concept.Biosensors · 2025Article
- GDNF receptor GFRα1 is necessary for the maintenance of dopaminergic neurons in the adult substantia nigra.PloS one · 2025Article
- Astrocyte Dysfunction Reflected in Ischemia-Induced Astrocyte-Derived Extracellular Vesicles: A Pilot Study on Acute Ischemic Stroke Patients.International journal of molecular sciences · 2024Article
- Decreasing the physical gap in the neural-electrode interface and related concepts to improve cochlear implant performance.Frontiers in neuroscience · 2024Review
- mRNA Abundance of Neurogenic Factors Correlates with Hearing Capacity in Auditory Brainstem Nuclei of the Rat.Life (Basel, Switzerland) · 2023Article
- Hearing loss: The final frontier of pharmacology.Pharmacology research & perspectives · 2022Review
- c-Myb protects cochlear hair cells from cisplatin-induced damage via the PI3K/Akt signaling pathway.Cell death discovery · 2022Article
- Age-Dependency of Neurite Outgrowth in Postnatal Mouse Cochlear Spiral Ganglion Explants.Brain sciences · 2020Article
- Pleiotrophin increases neurite length and number of spiral ganglion neurons in vitro.Experimental brain research · 2019Article
- Hearing regeneration and regenerative medicine: present and future approaches.Archives of medical science : AMS · 2019Article
- Advantageous environment of micro-patterned, high-density complementary metal-oxide-semiconductor electrode array for spiral ganglion neurons cultured in vitro.Scientific reports · 2018Article
- GFRA1: A Novel Molecular Target for the Prevention of Osteosarcoma Chemoresistance.International journal of molecular sciences · 2018Review
- Microelectrode array-induced neuronal alignment directs neurite outgrowth: analysis using a fast Fourier transform (FFT).European biophysics journal : EBJ · 2017Article
- NCAM-140 Translocation into Lipid Rafts Mediates the Neuroprotective Effects of GDNF.Molecular neurobiology · 2017Article
- GFRα1 Regulates Purkinje Cell Migration by Counteracting NCAM Function.Cell reports · 2017Article
- Role of Estrogens in the Size of Neuronal Somata of Paravaginal Ganglia in Ovariectomized Rabbits.BioMed research international · 2017Article
- Neurotrophic Factors and Their Potential Applications in Tissue Regeneration.Archivum immunologiae et therapiae experimentalis · 2016Review
- Organotypic Cultures as a Model to Study Adult Neurogenesis in CNS Disorders.Stem cells international · 2016Review
- Novel High Content Screen Detects Compounds That Promote Neurite Regeneration from Cochlear Spiral Ganglion Neurons.Scientific reports · 2015Article
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9 authors.
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Abstract
Glial cell line-derived neurotrophic factor (GDNF) increases survival and neurite extension of spiral ganglion neurons (SGNs), the primary neurons of the auditory system, via yet unknown signaling mechanisms. In other cell types, signaling is achieved by the GPI-linked GDNF family receptor α1 (GFRα1) via recruitment of transmembrane receptors: Ret (re-arranged during transformation) and/or NCAM (neural cell adhesion molecule). Here we show that GDNF enhances neuritogenesis in organotypic cultures of spiral ganglia from 5-day-old rats and mice. Addition of GFRα1-Fc increases this effect. GDNF/GFRα1-Fc stimulation activates intracellular PI3K/Akt and MEK/Erk signaling cascades as detected by Western blot analysis of cultures prepared from rats at postnatal days 5 (P5, before the onset of hearing) and 20 (P20, after the onset of hearing). Both cascades mediate GDNF stimulation of neuritogenesis, since application of the Akt inhibitor Wortmannin or the Erk inhibitor U0126 abolished GDNF/GFRα1-Fc stimulated neuritogenesis in P5 rats. Since cultures of P5 NCAM-deficient mice failed to respond by neuritogenesis to GDNF/GFRα1-Fc, we conclude that NCAM serves as a receptor for GDNF signaling responsible for neuritogenesis in early postnatal spiral ganglion.
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