Evidence map›Paper›PMID 23262059›Full record

ReviewEuropean journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences2013

A review of current nanoparticle and targeting moieties for the delivery of cancer therapeutics.

Stephanie D Steichen, Mary Caldorera-Moore, Nicholas A Peppas

Abstract readReview
In one paragraph

Review in European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 230 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
230citing papers in PubMed, 1 pooled it
15.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

230 citing papers in PubMed, 1 synthesis or guideline pooled it, 734 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. cDC1 Subtype-Specific In Vivo Targeting of Liposomes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Smart nanoplatforms for early detection and immune modulation in lung cancer.Frontiers in bioengineering and biotechnology · 2025
    Review
  19. Article
  20. Synthesis and Characterization of FeInternational journal of biomaterials · 2025
    Article

170 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Stephanie D SteichenDepartment of Biomedical Engineering, University of Texas at Austin, 1 University Station, C0800, Austin, TX 78712, USA.
Mary Caldorera-MooreDepartment of Biomedical Engineering, University of Texas at Austin, 1 University Station, C0800, Austin, TX 78712, USA; Department of Chemical Engineering, University of Texas at Austin, 1 University Station, C0400, Austin, TX 78712, USA.
Nicholas A PeppasDepartment of Biomedical Engineering, University of Texas at Austin, 1 University Station, C0800, Austin, TX 78712, USA; Department of Chemical Engineering, University of Texas at Austin, 1 University Station, C0400, Austin, TX 78712, USA. Electronic address: peppas@che.utexas.edu.
The University of Texas at Austin · US

Funding

TRANS-NETWORK PROJECTSU54CA143837 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CURLEY, STEVEN ALAN · 2009 to 2014
$10.8M
pH Sensitive Complex Hydrogels for Protein Drug ReleaseR01EB000246 · NIBIB · UNIVERSITY OF TEXAS AUSTIN · PI LOWMAN, ANTHONY M, PEPPAS, NICHOLAS A · 2002 to 2014
$3.8M
NCI NIH HHS U54 CA143837NCI NIH HHS U54-CA-143837NIBIB NIH HHS EB-00246-18NIBIB NIH HHS R01 EB000246
6 · The paper itself

Abstract

The tumor microenvironment provides unique challenges for the delivery of chemotherapeutic agents in doses that are effective while ensuring minimal systemic toxicity. The primary limitation of current therapeutics is a lack of specificity in delivery, as they target healthy and cancerous cells alike. The development of nanoscale carriers capable of delivering cancer therapies has the potential to overcome both systemic and tumor barriers and provide specific, targeted delivery. This review seeks to provide an overview of available nanoscale drug carriers by exploring the wide variety of developed nanostructures and the most commonly used moieties for targeted delivery. Additionally, the use of nanoscale carriers will be motivated by examining tumor physiology and the specific barriers present within both the tumor microenvironment and systemic delivery.

Indexed as

Drug Delivery SystemsModels, BiologicalAntineoplastic AgentsDelayed-Action PreparationsHumansNanoparticlesNeoplasmsTissue DistributionTumor MicroenvironmentAntineoplastic AgentsDelayed-Action Preparations

Identifiers

PMID23262059
PMCPMC3619023
OpenAlexW2072997205

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.