ArticleFree radical biology & medicine2013
Impact of hydrogen peroxide-driven Fenton reaction on mouse oocyte quality.
Article in Free radical biology & medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- The Ameliorative Effects of Carnosine on the In Vitro Developmental Competence of Bovine Oocytes.Antioxidants (Basel, Switzerland) · 2026Article
- Antioxidant Activity of SiOLangmuir : the ACS journal of surfaces and colloids · 2025Article
- Exploration of the mechanism and therapy of ovarian aging by targeting cellular senescence.Life medicine · 2025Review
- Hybrids of Gallic Acid@SiOLangmuir : the ACS journal of surfaces and colloids · 2024Article
- Effects of Nesting Material Provision and High-Dose Vitamin C Supplementation during the Peripartum Period on Prepartum Nest-Building Behavior, Farrowing Process, Oxidative Stress Status, Cortisol Levels, and Preovulatory Follicle Development in Hyperprolific Sows.Antioxidants (Basel, Switzerland) · 2024Article
- A review of nitric oxide and oxidative stress in typical ovulatory women and in the pathogenesis of ovulatory dysfunction in PCOS.Reproductive biology and endocrinology : RB&E · 2023Review
- Chronological age enhances aging phenomena and protein nitration in oocyte.Frontiers in endocrinology · 2023Article
- Iron overload triggering ECM-mediated Hippo/YAP pathway in follicle development: a hypothetical model endowed with therapeutic implications.Frontiers in endocrinology · 2023Review
- Premature ovarian insufficiency: a review on the role of oxidative stress and the application of antioxidants.Frontiers in endocrinology · 2023Review
- Accidental lead in contaminated pipe-borne water and dietary furan intake perturbs rats' hepatorenal function altering oxidative, inflammatory, and apoptotic balance.BMC pharmacology & toxicology · 2022Article
- Potential Role of Zinc in the COVID-19 Disease Process and its Probable Impact on Reproduction.Reproductive sciences (Thousand Oaks, Calif.) · 2022Review
- Melatonin interferes with COVID-19 at several distinct ROS-related steps.Journal of inorganic biochemistry · 2021Review
- Melatonin Attenuates Peroxynitrite-Induced Meiosis Dysfunction in Porcine Oocytes.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Samul-tang ameliorates oocyte damage due to cyclophosphamide-induced chronic ovarian dysfunction in mice.Scientific reports · 2020Article
- Loss of TIGAR Induces Oxidative Stress and Meiotic Defects in Oocytes from Obese Mice.Molecular & cellular proteomics : MCP · 2018Article
- Galactose and its Metabolites Deteriorate Metaphase II Mouse Oocyte Quality and Subsequent Embryo Development by Disrupting the Spindle Structure.Scientific reports · 2017Article
- Detection of Reactive Oxygen and Nitrogen Species by Electron Paramagnetic Resonance (EPR) Technique.Molecules (Basel, Switzerland) · 2017Review
- The Defensive Role of Cumulus Cells Against Reactive Oxygen Species Insult in Metaphase II Mouse Oocytes.Reproductive sciences (Thousand Oaks, Calif.) · 2016Article
- The Impact of Myeloperoxidase and Activated Macrophages on Metaphase II Mouse Oocyte Quality.PloS one · 2016Article
- Diffused Intra-Oocyte Hydrogen Peroxide Activates Myeloperoxidase and Deteriorates Oocyte Quality.PloS one · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Here we show that hydroxyl radical ((•)OH) generated through the Fenton reaction alters metaphase-II mouse oocyte microtubules (MT) and chromosomal alignment (CH). Metaphase-II mouse oocytes, obtained commercially, were grouped as follows: control, hydrogen peroxide (H2O2), Fe(II), and combined (Fe(II) +H2O2) treatments. After 7-10 min of incubation at 37 °C, MT and CH were evaluated on fixed and stained oocytes and scored by two blinded observers. Pearson χ(2) test and Fisher exact test were used to compare outcomes between controls and treated groups and also among the treated groups. Our results showed that poor scores for MT and CH increased significantly in oocytes treated with a combination of H2O2 and Fe(II) (p<0.001); oocytes treated with H2O2 alone or Fe(II) alone showed no or few changes compared to control. Comparison of oocyte groups that received increasing concentrations of H2O2 and a fixed amount of Fe(II) showed that 70-80% demonstrated poor scores in both MT and CH when pretreated with 5 μM H2O2, and this increased up to 90-100% when treated with 10-20 μM H2O2. Hydroxyl radical generated by H2O2-driven Fenton reaction deteriorates the metaphase-II mouse oocyte spindle and CH alignment, which is thought to be a potential cause of poor oocyte quality. Thus, free iron and/or ROS scavengers could attenuate the (•)OH-mediated spindle and chromosomal damage, thereby serving as a possible approach for further examination as a therapeutic option in inflammatory states.
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