Trial reportBehavioural brain research2013
Sex-based fMRI differences in obese humans in response to high vs. low energy food cues.
Trial report in Behavioural brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Neuroimaging Investigations of Obesity: a Review of the Treatment of Sex from 2010.Current obesity reports · 2023Pooled it
- Sex/gender differences in neural correlates of food stimuli: a systematic review of functional neuroimaging studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2017Pooled it
- Sex differences in central insulin action: Effect of intranasal insulin on neural food cue reactivity in adults with normal weight and overweight.International journal of obesity (2005) · 2022Trial
- Alterations in reward network functional connectivity are associated with increased food addiction in obese individuals.Scientific reports · 2021Trial
- The effects of energy balance, obesity-proneness and sex on the neuronal response to sweet taste.Behavioural brain research · 2015Trial
- Amodal brain activation and functional connectivity in response to high-energy-density food cues in obesity.Obesity (Silver Spring, Md.) · 2014Trial
- Ageing diminishes the modulation of human brain responses to visual food cues by meal ingestion.International journal of obesity (2005) · 2014Trial
- Liver fat mediates hippocampal-orbitofrontal reward circuit disruption and cognitive-emotional impairments in MASLD.Lipids in health and disease · 2025Article
- Gender Differences in Dietary Patterns and Eating Behaviours in Individuals with Obesity.Nutrients · 2024Article
- Expression of guanylate cyclase C in human prefrontal cortex depends on sex and feeding status.Frontiers in molecular neuroscience · 2024Article
- Binge Eating (BE) and Obesity: Brain Activity and Psychological Measures before and after Roux-En-Y Gastric Bypass (RYGB).Nutrients · 2023Article
- Sex Differences in Effects of Mood, Eating-Related Behaviors, and BMI on Food Appeal and Desire to Eat: A Cross-Sectional Survey Study.Nutrients · 2023Article
- Spatiotemporal profile of altered neural reactivity to food images in obesity: Reward system is altered automatically and predicts efficacy of weight loss intervention.Frontiers in neuroscience · 2023Article
- Cognitive Reappraisal Reduces the Influence of Threat on Food Craving.Affective science · 2022Article
- Neural circuits mediating food cue-reactivity: Toward a new model shaping the interplay of internal and external factors.Frontiers in nutrition · 2022Article
- Brain Responses to High-Calorie Visual Food Cues in Individuals with Normal-Weight or Obesity: An Activation Likelihood Estimation Meta-Analysis.Brain sciences · 2021Review
- Considering Sex as a Biological Variable in Basic and Clinical Studies: An Endocrine Society Scientific Statement.Endocrine reviews · 2021Article
- A Narrative Review of Sex Differences in Eating Disorders: Is There a Biological Basis?Clinical therapeutics · 2021Review
- Neuroimaging of Sex/Gender Differences in Obesity: A Review of Structure, Function, and Neurotransmission.Nutrients · 2020Review
- History of early life adversity is associated with increased food addiction and sex-specific alterations in reward network connectivity in obesity.Obesity science & practice · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Gender specific effects on human eating have been previously reported. Here we investigated sex-based differences in neural activation via whole-brain blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) in response to high energy-dense (high-ED) vs. low-ED visual and auditory food cues in obese men vs. women in both fed and fasted states. The results show that in response to high vs. low ED foods in the fed state, obese men (vs. women) had greater activation in brain areas associated with motor control regions (e.g. supplementary motor areas) whereas women showed greater activation in cognitive-related regions. In the fasted state, obese men had greater activation in a visual-attention region whereas obese women showed greater activation in affective and reward related processing regions (e.g. caudate). Overall the results support our a priori hypothesis that obese women (vs. men) have greater neural activation in regions associated with cognition and emotion-related brain regions. These findings may improve our understanding of sex specific differences among obese individuals in eating behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.