ArticleAmerican journal of infection control2013
MRSA nasal colonization burden and risk of MRSA infection.
Article in American journal of infection control, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Global epidemiology of asymptomatic colonisation of methicillin-resistantArchives of disease in childhood · 2024Pooled it
- Trends in methicillin-resistant Staphylococcus aureus detection-rates and antibiotic resistance profiles in a cancer hospital from 2015 to 2024.BMC infectious diseases · 2026Article
- Intranasal Testing and Treatment forJournal of the Pediatric Orthopaedic Society of North America · 2025Article
- Evaluation of a Pharmacist-Led Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2024Article
- An exploration of mechanisms underlyingmSphere · 2024Article
- Citral modulates human monocyte responses to Staphylococcus aureus infection.Scientific reports · 2021Article
- The Prevalence of Virulence Determinants and Antibiotic Resistance Patterns in Methicillin-ResistantPathogens (Basel, Switzerland) · 2021Article
- Burden of perianalInfection control and hospital epidemiology · 2020Article
- Healthcare-associated pneumonia: a prospective study in Spain.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2020Observational
- Current accounts of antimicrobial resistance: stabilisation, individualisation and antibiotics as infrastructure.Palgrave communications · 2019Article
- Antibiotic susceptibility profile and prevalence ofInfection and drug resistance · 2019Article
- Factors associated with bacteraemia due to multidrug-resistant organisms among bacteraemic patients with multidrug-resistant organism carriage: a case control study.Antimicrobial resistance and infection control · 2018Article
- High Perineal and Overall Frequency of Staphylococcus aureus in People Who Inject Drugs, Compared to Non-Injectors.Current microbiology · 2017Article
- Utilizing Moist or Dry Swabs for the Sampling of Nasal MRSA Carriers? An In Vivo and In Vitro Study.PloS one · 2016Article
- Methicillin-Resistant Staphylococcus aureus in Saarland, Germany: The Long-Term Care Facility Study.PloS one · 2016Article
- Does Staphylococcus aureus nasal carriage require eradication prior to elective ambulatory surgery in children?Pediatric surgery international · 2014Article
- A nasal epithelial receptor for Staphylococcus aureus WTA governs adhesion to epithelial cells and modulates nasal colonization.PLoS pathogens · 2014Article
- Impact of a surveillance screening program on rates of methicillin-resistant Staphylococcus aureus infections with a comparison of surgical versus nonsurgical patients.Proceedings (Baylor University. Medical Center) · 2014Article
- High Level Expression and Purification of Atl, the Major Autolytic Protein of Staphylococcus aureus.International journal of microbiology · 2014Article
- Applying Convergent Immunity to Innovative Vaccines Targeting Staphylococcus aureus.Frontiers in immunology · 2014Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundStaphylococcus aureus nasal colonization burden has been identified as a risk factor for infection. This study evaluates methicillin-resistant S aureus (MRSA) nasal burden, as defined by the cycle threshold (Ct) and risk of subsequent infection.
methodsIn a retrospective cohort study, United States veterans were classified into 3 MRSA nasal colonization groups: noncarriers, low burden (Ct > 24 cycles), and high burden (Ct ≤ 24 cycles). MRSA infections were identified prospectively, and clinical information was obtained by chart review. Multivariate logistic regression assessed the association of MRSA nasal burden and risk of MRSA infection.
resultsDuring 4-years of follow-up, 4.3% of noncarriers, 18.5% of low burden, and 17.2% of high burden developed a MRSA infection. In multivariate analysis, MRSA nasal colonization was a risk factor for MRSA infection (P = .008) with low burden (risk ratio [RR], 3.62; 95% confidence interval [CI]: 1.47-8.93) and high burden (RR, 2.71; 95% CI: 0.95-7.72) associated with subsequent MRSA infection when compared with noncarriers. When compared with low burden, high burden nasal carriers were not at increased risk of infection (RR, 0.75; 95% CI 0.36-1.55).
conclusionMRSA nasal colonization was a risk factor for MRSA infection. High nasal burden of MRSA did not increase the risk of infection.
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Registered trials
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