ArticleDevelopmental cell2013
Repeated, long-term cycling of putative stem cells between niches in a basal chordate.
Article in Developmental cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed.
- Lifelong Invertebrate Chordate Central Nervous System Regeneration is Driven by a Migrating Pool of Conserved Neural Stem Cells program.bioRxiv : the preprint server for biology · 2026Article
- Multi-stage single-cell atlas of a chordate non-embryonic development unveils dedifferentiating bud founder cells.Nature communications · 2026Article
- Coating materials enhance urochordate primary cell culture adherence.In vitro cellular & developmental biology. Animal · 2026Article
- Electrical stimulation promotes longevity and regeneration in a colonial chordate.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Survival Benefits Outweigh Germline Competition Costs in Kin Chimeras.bioRxiv : the preprint server for biology · 2026Article
- Germline stem cell isolation, lineage tracing, and aging in a protochordate.bioRxiv : the preprint server for biology · 2025Article
- From fragment to form: whole-body regeneration in a model urochordate.NPJ Regenerative medicine · 2025Review
- Electrical Stimulation Rejuvenates Tunicates: Altered Stem Cell and Immune Activity.bioRxiv : the preprint server for biology · 2025Article
- Speed vs completeness: a comparative study of solitary and colonial tunicate embryogenesis.Frontiers in cell and developmental biology · 2025Article
- PIWI proteins and piRNAs: key regulators of stem cell biology.Frontiers in cell and developmental biology · 2025Review
- Stem cell-mediated development, regeneration, chimerism, and aging in the colonial chordate Botryllus schlosseri.Genesis (New York, N.Y. : 2000) · 2023Article
- Improved Media Formulations for Primary Cell Cultures Derived from a Colonial Urochordate.Cells · 2023Article
- The novel Orshina Rhythm in a colonial urochordate signifies the display of recurrent aging/rejuvenation sequels.Scientific reports · 2023Article
- Transcriptional Analysis of the Endostyle Reveals Pharyngeal Organ Functions in Ascidian.Biology · 2023Article
- The salamander blastema within the broader context of metazoan regeneration.Frontiers in cell and developmental biology · 2023Review
- Contributions from both the brain and the vascular network guide behavior in the colonial tunicate Botryllus schlosseri.The Journal of experimental biology · 2022Article
- Transposon control as a checkpoint for tissue regeneration.Development (Cambridge, England) · 2022Article
- Two distinct evolutionary conserved neural degeneration pathways characterized in a colonial chordate.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A pan-metazoan concept for adult stem cells: the wobbling Penrose landscape.Biological reviews of the Cambridge Philosophical Society · 2022Article
- Articulating the "stem cell niche" paradigm through the lens of non-model aquatic invertebrates.BMC biology · 2022Review
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13 authors.
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Abstract
The mechanisms that sustain stem cells are fundamental to tissue maintenance. Here, we identify "cell islands" (CIs) as a niche for putative germ and somatic stem cells in Botryllus schlosseri, a colonial chordate that undergoes weekly cycles of death and regeneration. Cells within CIs express markers associated with germ and somatic stem cells and gene products that implicate CIs as signaling centers for stem cells. Transplantation of CIs induced long-term germline and somatic chimerism, demonstrating self-renewal and pluripotency of CI cells. Cell labeling and in vivo time-lapse imaging of CI cells reveal waves of migrations from degrading CIs into developing buds, contributing to soma and germline development. Knockdown of cadherin, which is highly expressed within CIs, elicited the migration of CI cells to circulation. Piwi knockdown resulted in regeneration arrest. We suggest that repeated trafficking of stem cells allows them to escape constraints imposed by the niche, enabling self-preservation throughout life.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.