ArticleThe Journal of urology2013
Strontium substitution for calcium in lithogenesis.
Article in The Journal of urology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Trace element signatures and regional differences in kidney stones: insights from a high-prevalence region.Urolithiasis · 2025Article
- Elemental composition analysis of calcium-based urinary stones via laser-induced breakdown spectroscopy for enhanced clinical insights.Scientific reports · 2025Article
- Metal(oid) profiling of the common site of osteoporotic fractures with bone microarchitecture correlation analysis: a comparative study of hip fracture patients and healthy individuals.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Factors affecting the concentration of metals and metalloids in the kidneys of a top predator, the Eurasian Buzzard (Buteo buteo) wintering in farmland in Poland.Environmental science and pollution research international · 2024Article
- Article
- Reconstructing Middle and Upper Paleolithic human mobility in Portuguese Estremadura through laser ablation strontium isotope analysis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Use of strontium isotope ratios in geolocation of Guatemalan population: Potential role in identification of remains.Journal of forensic sciences · 2022Article
- Spectroscopic Characterization of Urinary Stones Richening with Calcium Oxalate.Biological trace element research · 2021Article
- Article
- Evaluation of La(XT), a novel lanthanide compound, in an OVX rat model of osteoporosis.Bone reports · 2021Article
- Effects of Incubation of Human Brain Microvascular Endothelial Cells and Astrocytes with Pyridostigmine Bromide, DEET, or Permethrin in the Absence or Presence of Metal Salts.International journal of environmental research and public health · 2020Article
- Analysis of stones formed in the human gall bladder and kidney using advanced spectroscopic techniques.Biophysical reviews · 2020Review
- Urinary Essential Elements of Young Children with Autism Spectrum Disorder and their Mothers.Research in autism spectrum disorders · 2020Article
- Article
- Urinary Stone Disease: Advancing Knowledge, Patient Care, and Population Health.Clinical journal of the American Society of Nephrology : CJASN · 2016Review
- The elementome of calcium-based urinary stones and its role in urolithiasis.Nature reviews. Urology · 2015Review
- Elemental Content of Calcium Oxalate Stones from a Canine Model of Urinary Stone Disease.PloS one · 2015Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
purposeStrontium has chemical similarity to calcium, which enables the replacement of calcium by strontium in biomineralization processes. Incorporating strontium into human bone and teeth has been studied extensively but little research has been performed of the incorporation of strontium into urinary calculi. We used synchrotron based x-ray fluorescence and x-ray absorption techniques to examine the presence of strontium in different types of human kidney stones. MATERIALS AND
methodsMultiple unique human stone samples were obtained via consecutive percutaneous nephrolithotomies/ureteroscopies. A portion of each stone was sent for standard laboratory analysis and a portion was retained for x-ray fluorescence and x-ray absorption measurements. X-ray fluorescence and x-ray absorption measurements determined the presence, spatial distribution and speciation of strontium in each stone sample.
resultsTraditional kidney stone analyses identified calcium oxalate, calcium phosphate, uric acid and cystine stones. X-ray fluorescence measurements identified strontium in all stone types except pure cystine. X-ray fluorescence elemental mapping of the samples revealed co-localization of calcium and strontium. X-ray absorption measurements of the calcium phosphate stone showed strontium predominately present as strontium apatite.
conclusionsAdvanced x-ray fluorescence imaging identified strontium in all calcium based stones, present as strontium apatite. This finding may be critical since apatite is thought to be the initial nidus for calcium stone formation. Strontium is not identified by standard laboratory stone analyses. Its substitution for calcium can be reliably identified in stones from multiple calcium based stone formers, which may offer opportunities to gain insight into early events in lithogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.