ReviewAutonomic neuroscience : basic & clinical2013
Role of the hypothalamic arcuate nucleus in cardiovascular regulation.
Review in Autonomic neuroscience : basic & clinical, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 54 citations in OpenAlex.
- Mechanisms of Acupuncture on the Neurovascular Unit in Migraine: A Narrative Review.European journal of neurology · 2026Review
- Angiotensin-(1-7) Activates Proopiomelanocortin Neurons in the Arcuate Nucleus.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Advances in the regulation of bone metabolism by central nuclei: a new perspective on the brain-bone axis.Frontiers in neuroscience · 2026Review
- Acetate concentration correlates with MSNA in patients with resistant hypertension.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Central nervous system mechanisms of salt-sensitive hypertension.Physiological reviews · 2025Review
- Acute nicotine activates orectic and inhibits anorectic brain regions in rats exposed to chronic nicotine.Neuropharmacology · 2024Article
- Microglia in physiological conditions and the importance of understanding their homeostatic functions in the arcuate nucleus.Frontiers in immunology · 2024Review
- Chronic Pain-Associated Cardiovascular Disease: The Role of Sympathetic Nerve Activity.International journal of molecular sciences · 2023Review
- Food preferences after bariatric surgery: a review update.Internal and emergency medicine · 2023Review
- Burning Mouth Syndrome and Hypertension: Prevalence, Gender Differences and Association with Pain and Psycho-Social Characteristics-A Case Control Study.International journal of environmental research and public health · 2023Article
- The renin-angiotensin system biomolecular cascade: a 2022 update of newer insights and concepts.Kidney international supplements · 2022Review
- Prevalence of hypertension and correlation with mental health in women with burning mouth syndrome: A case-control study.Frontiers in cardiovascular medicine · 2022Article
- Emotional and autonomic response to visual erotic stimulation in patients with functional hypothalamic amenorrhea.Frontiers in endocrinology · 2022Article
- Activation of hypothalamic AgRP and POMC neurons evokes disparate sympathetic and cardiovascular responses.American journal of physiology. Heart and circulatory physiology · 2020Article
- Oxytocin-monomeric red fluorescent protein 1 synthesis in the hypothalamus under osmotic challenge and acute hypovolemia in a transgenic rat line.Physiological reports · 2020Article
- Article
- Sex-dependent effects of chronic variable stress on discrete corticotropin-releasing factor receptor 1 cell populations.Physiology & behavior · 2020Article
- The Mechanism of Acupuncture in Treating Essential Hypertension: A Narrative Review.International journal of hypertension · 2019Review
- New insight into inter-organ crosstalk contributing to the pathogenesis of non-alcoholic fatty liver disease (NAFLD).Protein & cell · 2018Review
- The increased expression of GABA receptors within the arcuate nucleus is associated with high intraocular pressure.Molecular vision · 2018Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Recently the hypothalamic arcuate nucleus (Arc) has been implicated in cardiovascular regulation. Both pressor and depressor responses can be elicited by the chemical stimulation of the Arc. The direction of cardiovascular responses (increase or decrease) elicited from the Arc depends on the baseline blood pressure. The pressor responses are mediated via increase in sympathetic nerve activity and involve activation of the spinal ionotropic glutamate receptors. Arc-stimulation elicits tachycardic responses which are mediated via inhibition of vagal input and excitation of sympathetic input to the heart. The pathways within the brain mediating the pressor and tachycardic responses elicited from the Arc have not been delineated. The depressor responses to the Arc-stimulation are mediated via the hypothalamic paraventricular nucleus (PVN). Gamma aminobutyric acid type A receptors, neuropeptide Y1 receptors, and opiate receptors in the PVN mediate the depressor responses elicited from the Arc. Some circulating hormones (e.g., leptin and insulin) may reach the Arc via the leaky blood-brain barrier and elicit their cardiovascular effects. Although the Arc is involved in mediating the cardiovascular responses to intravenously injected angiotensin II and angiotensin-(1-12), these effects may not be due to leakage of these peptides across the blood-brain barrier in the Arc; instead, circulating angiotensins may act on neurons in the SFO and mediate cardiovascular actions via the projections of SFO neurons to the Arc. Cardiovascular responses elicited by acupuncture have been reported to be mediated by direct and indirect projections of the Arc to the RVLM.
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