ArticleMagnetic resonance imaging2013
Measurement and correction of stimulated echo contamination in T2-based iron quantification.
Article in Magnetic resonance imaging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Assessment of iron nanoparticle distribution in mouse models using ultrashort-echo-time MRI.NMR in biomedicine · 2022Article
- Relaxivity-iron calibration in hepatic iron overload: Reproducibility and extension of a Monte Carlo model.NMR in biomedicine · 2021Article
- Optimisation of T2 and T2* sequences in MRI for better quantification of iron on transfused dependent sickle cell patients.Scientific reports · 2021Article
- MR characterization of hepatic storage iron in transfusional iron overload.Journal of magnetic resonance imaging : JMRI · 2014Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
The purpose of this study was to characterize the effects of stimulated echo contamination on MR-based iron measurement derived from quantitative T2 images and develop a method for retrospective correction. Two multiple spin-echo (MSE) pulse sequences were implemented with different amounts of stimulated echo contamination. Agarose-based phantoms were constructed that simulate the relaxation and susceptibility properties of tissue with different concentrations of dispersed (ferritin-like) and aggregated (hemosiderin-like) iron. Additionally, myocardial iron was assessed in nine human subjects with transfusion iron overload. These data were used to determine the influence of stimulated echoes on iron measurements made by an MR-based iron quantification model that can separately measure dispersed and aggregated iron. The study found that stimulated echo contamination caused an underestimation of dispersed (ferritin-like) iron and an overestimation of aggregated (hemosiderin-like) iron when applying this model. The relationship between the measurements made with and without stimulated echo appears to be linear. The findings suggest that while it is important to use MSE sequences with minimal stimulated echo in T2-based iron quantification, it appears that data acquired with sub-optimal sequences can be retrospectively corrected using the methodology described here.
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Registered trials
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