ReviewNeuron2012
The role of medial prefrontal cortex in memory and decision making.
Review in Neuron, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 757 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
757 citing papers in PubMed, 5 syntheses or guidelines pooled it, 1,548 citations in OpenAlex.
- Brain Structural Abnormalities in Addiction Disorders: Transdiagnostic Meta-Analyses.Human brain mapping · 2026Pooled it
- Functional division of the prefrontal lobe of the brain: coordinate-based neuroimaging meta-analysis.Physical and engineering sciences in medicine · 2025Pooled it
- Neural correlates of implicit emotion regulation in mood and anxiety disorders: an fMRI meta-analytic review.Scientific reports · 2025Pooled it
- Cerebellar tDCS and pain modulation: a critical integrative and systematic review.Frontiers in neurology · 2025Pooled it
- Specificity in the commonalities of inhibition control: using meta-analysis and regression analysis to identify the key brain regions in psychiatric disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2024Pooled it
- Multi-Site Theta-tACS Improves Memory and Language Performance and Associated Local and Remote Functional Connectivity in Mild Cognitive Impairment.CNS neuroscience & therapeutics · 2025Trial
- Transcranial direct current stimulation of the prefrontal and visual cortices diversely affects early and late perceptual learning.Brain and behavior · 2024Trial
- Temporal Interference Modulates Medial Temporal and Frontoparietal Activity During Mnemonic Discrimination: A High-Resolution Whole-Brain fMRI Investigation.Hippocampus · 2026Article
- Extinction-recruited prefrontal-hypothalamic pathway encodes positive affect to sustain fear extinction in posttraumatic stress mouse model.The Journal of clinical investigation · 2026Article
- Good vibes keep worries at bay: a prefrontal-hypothalamic pathway engages positive affect to mitigate fear.The Journal of clinical investigation · 2026Article
- Early adversity promotes adolescent avoidance behavior by enhancing prefrontal-amygdala communication through CRHbioRxiv : the preprint server for biology · 2026Article
- A circuit dissection of perception-action decoupling in S-ketamine-induced hallucination-like states.Molecular psychiatry · 2026Article
- Modulation of prefrontal theta oscillations slows social cognition.Cognitive, affective & behavioral neuroscience · 2026Article
- Reward Modality and Task Complexity Shape Learning Dynamics during Multi-decision Sequential Navigation.eNeuro · 2026Article
- Acute alcohol triggers rank-specific social ascent through a prefrontal-accumbens circuit in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- NMDA receptor ablation in medial prefrontal cortex disrupts value updating and reward history integration.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Distinctly structured social behavior across three rodent strains is associated with different neural activity patterns.iScience · 2026Article
- Neural competition between prefrontal and auditory cortex constrains novel sound strategy learning.Science advances · 2026Article
- Dietary phytoestrogen ameliorates ovarian toxicant-induced neurotoxicity: mechanistic and metabolic insights.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- mPFC hemorrhage induces hippocampal CA1 dendritic spine plasticity and attentional deficits in mice.Research in pharmaceutical sciences · 2026Article
697 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Some have claimed that the medial prefrontal cortex (mPFC) mediates decision making. Others suggest mPFC is selectively involved in the retrieval of remote long-term memory. Yet others suggests mPFC supports memory and consolidation on time scales ranging from seconds to days. How can all these roles be reconciled? We propose that the function of the mPFC is to learn associations between context, locations, events, and corresponding adaptive responses, particularly emotional responses. Thus, the ubiquitous involvement of mPFC in both memory and decision making may be due to the fact that almost all such tasks entail the ability to recall the best action or emotional response to specific events in a particular place and time. An interaction between multiple memory systems may explain the changing importance of mPFC to different types of memories over time. In particular, mPFC likely relies on the hippocampus to support rapid learning and memory consolidation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.