ArticleACS nano2013
Smart vaults: thermally-responsive protein nanocapsules.
Article in ACS nano, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 61 citations in OpenAlex.
- Vault Particles in Cancer Progression, Multidrug Resistance, and Drug Delivery: Current Insights and Future Applications.International journal of molecular sciences · 2025Review
- Article
- Review
- Protein-based nanoparticles in cancer vaccine development.Nanomedicine : nanotechnology, biology, and medicine · 2019Review
- Review
- Poly(N-isopropylacrylamide) and Copolymers: A Review on Recent Progresses in Biomedical Applications.Gels (Basel, Switzerland) · 2017Review
- Article
- Engineering protein nanocages as carriers for biomedical applications.NPG Asia materials · 2017Review
- One-component nanomedicine.Journal of controlled release : official journal of the Controlled Release Society · 2015Review
- Dual pH- and Temperature-Responsive Protein Nanoparticles.European polymer journal · 2015Article
- A pH-responsive soluble polymer-based homogeneous system for fast and highly efficientChemical science · 2015Article
- Nanotechnology to augment immunotherapy for the treatment of glioblastoma multiforme.Journal of neuro-oncology · 2015Review
- Molecular glues for manipulating enzymes: trypsin inhibition by benzamidine-conjugated molecular glues.Chemical science · 2015Article
- Synthesis and anticoagulant activity of polyureas containing sulfated carbohydrates.Biomacromolecules · 2014Article
- Thermoresponsive magnetic hydrogels as theranostic nanoconstructs.ACS applied materials & interfaces · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Synthetic modification of a recombinant protein cage called a vault with stimuli-responsive smart polymers provides access to a new class of biohybrid materials; the polymer nanocapsules retain the structure of the protein cage and exhibit the responsive nature of the polymer. Vaults are naturally occurring ubiquitous ribonucleoprotein particles 41 × 41 × 72.5 nm composed of a protein shell enclosing multiple copies of two proteins and multiple copies of one or more small untranslated RNAs. Recombinant vaults are structurally identical but lack the vault content. Poly(N-isopropylacrylamide) (pNIPAAm), a polymer responsive to heat, was conjugated to recombinant vaults that were composed of ~78 copies of the major vault protein (MVP) modified to contain a cysteine rich region at the N-terminus (CP-MVP). The polymer was synthesized using reversible addition-fragmentation chain transfer (RAFT) polymerization to have a dansyl group at the alpha end and modified to have a thiol-reactive pyridyl disulfide at the omega end, which readily coupled to CP-MVP vaults. The resulting vault nanocapsules underwent reversible aggregation upon heating above the lower critical solution temperature (LCST) of the polymer as determined by electron microscopy (EM), dynamic light scattering experiments, and UV-vis turbidity analysis. The vault structure remained entirely intact throughout the phase transition; suggesting its use in a myriad of biomedical and biotechnology applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.