ArticleThe Journal of asthma : official journal of the Association for the Care of Asthma2013
Spirometry and PRAM severity score changes during pediatric acute asthma exacerbation treatment in a pediatric emergency department.
Article in The Journal of asthma : official journal of the Association for the Care of Asthma, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Humidified and standard oxygen therapy in acute severe asthma in children (HUMOX): A pilot randomised controlled trial.PloS one · 2022Trial
- Magnesium in acute pediatric asthma in the emergency department (MAGICIAN)-A multicentre randomized controlled clinical trial protocol.PloS one · 2026Article
- Analysis of the asthma scores recommended in guidelines for children presenting to the emergency department: a Pediatric Emergency Research Networks study.Archives of disease in childhood · 2025Observational
- Performance of the Asthma Clinical Score in the Evaluation of Acute Asthma in the Emergency Department.Pediatric pulmonology · 2025Observational
- Use of lung ultrasound in school-aged children with wheezing.Frontiers in pediatrics · 2022Article
- Pilot Study of Peak Plasma Concentration After High-Dose Oral Montelukast in Children With Acute Asthma Exacerbations.Journal of clinical pharmacology · 2021Observational
- Paediatrics: how to manage acute asthma exacerbations.Drugs in context · 2021Review
- Emergency department treatment of asthma in children: A review.Journal of the American College of Emergency Physicians open · 2020Review
- Direct concurrent comparison of multiple pediatric acute asthma scoring instruments.The Journal of asthma : official journal of the Association for the Care of Asthma · 2017Article
- Pediatric asthma severity score is associated with critical care interventions.World journal of clinical pediatrics · 2017Article
- The asthma prediction rule to decrease hospitalizations for children with asthma.Current opinion in allergy and clinical immunology · 2016Review
- Pulse Oximeter Plethysmograph Estimate of Pulsus Paradoxus as a Measure of Acute Asthma Exacerbation Severity and Response to Treatment.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2016Observational
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo examine the time-dependent changes of spirometry (percent-predicted forced expiratory volume in 1 second [%FEV(1)]) and the Pediatric Respiratory Assessment Measure (PRAM) during the treatment of acute asthma exacerbations. STUDY
designWe conducted a prospective study of participants aged 5-17 years with acute asthma exacerbations managed in a Pediatric Emergency Department. %FEV(1) and the PRAM were recorded pretreatment and at 2 and 4 hours. We examined responses at 2 and 4 hours following treatment and assessed whether the changes of %FEV(1) and of the PRAM differed during the first and the second 2-hour treatment periods.
resultsAmong 503 participants, median [interquartile range, IQR] age was 8.8 [6.9, 11.4], 61% were male, and 63% were African-American. There was significant mean change of %FEV(1) during the first (+15.4%; 95% CI 13.7 to 17.1; p < .0001), but not during the second (+1.5%; 95% CI -0.8 to 3.8; p = .21), 2-hour period and of the PRAM during the first (-2.1 points; 95% CI -2.3 to -1.9; p < .0001) and the second (-1.0 point; 95% CI -1.3 to -0.7; p < .0001) 2-hour periods.
conclusionsMost improvement of lung function and clinical severity occur in the first 2 hours of treatment. Among pediatric patients with acute asthma exacerbations, the PRAM detects significant and clinically meaningful change of severity during the second 2-hour treatment, whereas spirometry does not. This suggests that spirometry and clinical severity scores do not have similar trajectories and that clinical severity scores may be more sensitive to clinical change of acute asthma severity than spirometry.
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