ArticleBMC cardiovascular disorders2012
QTc interval prolongation in HIV-infected patients: a case-control study by 24-hour Holter ECG recording.
Article in BMC cardiovascular disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- A meta-analysis of HIV and heart rate variability in the era of antiretroviral therapy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2016Pooled it
- Prolonged QT Interval in HIV-1 Infected Humanized Mice Treated Chronically with Dolutegravir/Tenofovir Disoproxil Fumarate/Emtricitabine.International journal of molecular sciences · 2026Article
- Association between exposure to Efavirenz and substrates of dysrhythmia in HIV-infected young adults.Clinical cardiology · 2021Article
- Linear and non-linear analysis of heart rate variability in HIV-positive patients on two different antiretroviral therapy regimens.BMC infectious diseases · 2021Article
- Reduced functional connectivity between ventromedial prefrontal cortex and insula relates to longer corrected QT interval in HIV+ and HIV- individuals.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2017Article
- HIV-1-Tat excites cardiac parasympathetic neurons of nucleus ambiguus and triggers prolonged bradycardia in conscious rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- QT prolongation in HIV-positive patients: Review article.Indian heart journalReview
- Electrocardiographic findings in a cross-sectional study of human immunodeficiency virus (HIV) patients in Enugu, south-east Nigeria.Cardiovascular journal of AfricaArticle
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8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAim of the study was to assess QTc interval by a 24-hour ECG recording in a group of HIV-infected individuals with a basal prolonged QTc. The risk factors associated with QTc prolongation and the indices of cardiovascular autonomic control were also evaluated.
methodsA case-control study was performed using as cases 32 HIV-infected patients with prolonged (>440 msec) QTc interval as assessed by Holter ECG, and as controls 64 HIV-infected subjects with normal QTc interval. Autonomic function was evaluated by heart rate variability analysis during 24-hour recording.
resultsDuration of HIV disease was significantly longer among cases than among controls (p=0.04). Waist/hip ratio was also higher among cases than among controls (p=0.05). Frequency domain analysis showed the absence of physiologic decrease of low frequency (LF) in the night period in both cases and controls. The LF night in cases showed a statistically significant reduction when compared with controls (p=0.007).
conclusionsIn our study group, QTc interval prolongation was associated with a longer duration of HIV infection and with a greater waist/hip ratio. HIV patients with QTc interval prolongation and with a longer duration of HIV infection were more likely to have an impairment of parasympathetic and sympathetic cardiac component.
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