ArticleMalaria journal2012
Expression of a type B RIFIN in Plasmodium falciparum merozoites and gametes.
Article in Malaria journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
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- Transmission-Blocking Vaccines: Old Friends and New Prospects.Infection and immunity · 2019Review
- '2TM proteins': an antigenically diverse superfamily with variable functions and export pathways.PeerJ · 2018Article
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- An ApiAP2 member regulates expression of clonally variant genes of the human malaria parasite Plasmodium falciparum.Scientific reports · 2017Article
- Malaria Epigenetics.Cold Spring Harbor perspectives in medicine · 2017Review
- Epitopes of anti-RIFIN antibodies and characterization of rif-expressing Plasmodium falciparum parasites by RNA sequencing.Scientific reports · 2017Article
- Antibody responses to surface antigens of Plasmodium falciparum gametocyte-infected erythrocytes and their relation to gametocytaemia.Parasite immunology · 2016Article
- Immune Escape Strategies of Malaria Parasites.Frontiers in microbiology · 2016Review
- Screening of potential targets in Plasmodium falciparum using stage-specific metabolic network analysis.Molecular diversity · 2015Article
- Paths to a malaria vaccine illuminated by parasite genomics.Trends in genetics : TIG · 2015Review
- Parasite epigenetics and immune evasion: lessons from budding yeast.Epigenetics & chromatin · 2013Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe ability of Plasmodium falciparum to undergo antigenic variation, by switching expression among protein variants encoded by multigene families, such as var, rif and stevor, is key to the survival of this parasite in the human host. The RIFIN protein family can be divided into A and B types based on the presence or absence of a 25 amino acid motif in the semi-conserved domain. A particular type B RIFIN, PF13_0006, has previously been shown to be strongly transcribed in the asexual and sexual stages of P. falciparum in vitro.
methodsAntibodies to recombinant PF13_0006 RIFIN were used in immunofluorescence and confocal imaging of 3D7 parasites throughout the asexual reproduction and sexual development to examine the expression of PF13_0006. Furthermore, reactivity to recombinant PF13_0006 was measured in plasma samples collected from individuals from both East and West African endemic areas.
resultsThe PF13_0006 RIFIN variant appeared expressed by both released merozoites and gametes after emergence. 7.4% and 12.1% of individuals from East and West African endemic areas, respectively, carry plasma antibodies that recognize recombinant PF13_0006, where the antibody responses were more common among older children.
conclusionsThe stage specificity of PF13_0006 suggests that the diversity of RIFIN variants has evolved to provide multiple specialized functions in different stages of the parasite life cycle. These data also suggest that RIFIN variants antigenically similar to PF13_0006 occur in African parasite populations.
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