ArticleBMC genomics2012
Genome-guided analysis of physiological and morphological traits of the fermentative acetate oxidizer Thermacetogenium phaeum.
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 63 citations in OpenAlex.
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- Comparative Physiology and Genomics of Thermincola and Carboxydocella Strains and Description of Two Novel Isolates.Environmental microbiology · 2026Article
- Metagenomic Exploration Uncovers Several Novel 'Candidatus' Species Involved in Acetate Metabolism in High-Ammonia Thermophilic Biogas Processes.Microbial biotechnology · 2025Article
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- Metabolism of novel potential syntrophic acetate-oxidizing bacteria in thermophilic methanogenic chemostats.Applied and environmental microbiology · 2024Article
- Catabolism and interactions of syntrophic propionate- and acetate oxidizing microorganisms under mesophilic, high-ammonia conditions.Frontiers in microbiology · 2024Article
- Synergy and competition during the anaerobic degradation of N-acetylglucosamine in a methane-emitting, subarctic, pH-neutral fen.Frontiers in microbiology · 2024Article
- Progresses and challenges of engineering thermophilic acetogenic cell factories.Frontiers in microbiology · 2024Review
- Diverse electron carriers drive syntrophic interactions in an enriched anaerobic acetate-oxidizing consortium.The ISME journal · 2023Article
- Reprogramming the metabolism of an acetogenic bacterium to homoformatogenesis.The ISME journal · 2023Article
- Engineering Acetogenic Bacteria for Efficient One-Carbon Utilization.Frontiers in microbiology · 2022Review
- Reductive evolution and unique predatory mode in the CPR bacterium Vampirococcus lugosii.Nature communications · 2021Article
- Insights into Ammonia Adaptation and Methanogenic Precursor Oxidation by Genome-Centric Analysis.Environmental science & technology · 2020Article
- Microbial Life in the Deep Subsurface Aquifer Illuminated by Metagenomics.Frontiers in microbiology · 2020Article
- Energy-Conserving Enzyme Systems Active During Syntrophic Acetate Oxidation in the Thermophilic BacteriumFrontiers in microbiology · 2019Article
- Alternative Pathways of Acetogenic Ethanol and Methanol Degradation in the Thermophilic AnaerobeFrontiers in microbiology · 2019Article
- Detection of novel syntrophic acetate-oxidizing bacteria from biogas processes by continuous acetate enrichment approaches.Microbial biotechnology · 2018Article
- Article
- Metabolism and Occurrence of Methanogenic and Sulfate-Reducing Syntrophic Acetate Oxidizing Communities in Haloalkaline Environments.Frontiers in microbiology · 2018Article
- Salt Marsh Bacterial Communities before and after the Deepwater Horizon Oil Spill.Applied and environmental microbiology · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThermacetogenium phaeum is a thermophilic strictly anaerobic bacterium oxidizing acetate to CO(2) in syntrophic association with a methanogenic partner. It can also grow in pure culture, e.g., by fermentation of methanol to acetate. The key enzymes of homoacetate fermentation (Wood-Ljungdahl pathway) are used both in acetate oxidation and acetate formation. The obvious reversibility of this pathway in this organism is of specific interest since syntrophic acetate oxidation operates close to the energetic limitations of microbial life.
resultsThe genome of Th. phaeum is organized on a single circular chromosome and has a total size of 2,939,057 bp. It comprises 3.215 open reading frames of which 75% could be assigned to a gene function. The G+C content is 53.88 mol%. Many CRISPR sequences were found, indicating heavy phage attack in the past. A complete gene set for a phage was found in the genome, and indications of phage action could also be observed in culture. The genome contained all genes required for CO(2) reduction through the Wood-Ljungdahl pathway, including two formyl tetrahydrofolate ligases, three carbon monoxide dehydrogenases, one formate hydrogenlyase complex, three further formate dehydrogenases, and three further hydrogenases. The bacterium contains a menaquinone MQ-7. No indications of cytochromes or Rnf complexes could be found in the genome.
conclusionsThe information obtained from the genome sequence indicates that Th. phaeum differs basically from the three homoacetogenic bacteria sequenced so far, i.e., the sodium ion-dependent Acetobacterium woodii, the ethanol-producing Clostridium ljungdahlii, and the cytochrome-containing Moorella thermoacetica. The specific enzyme outfit of Th. phaeum obviously allows ATP formation both in acetate formation and acetate oxidation.
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