ArticleArthritis research & therapy2012
Ghrelin and adipokines as circulating markers of disease activity in patients with Takayasu arteritis.
Article in Arthritis research & therapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Biomarkers in Primary Systemic Vasculitides: Narrative Review.International journal of molecular sciences · 2026Review
- Serum leptin, a potential predictor of long-term angiographic progression in Takayasu's arteritis.International journal of rheumatic diseases · 2019Article
- Biomarkers in Vasculitides of the Nervous System.Frontiers in neurology · 2019Review
- Low prevalence of obesity in Behçet's disease is associated with high obestatin level.European journal of rheumatology · 2017Article
- The Role of Perivascular Adipose Tissue in Non-atherosclerotic Vascular Disease.Frontiers in physiology · 2017Review
- Outcome measures for Takayasu's arteritis.Current opinion in rheumatology · 2015Review
- Role of inflammatory markers in Takayasu arteritis disease monitoring.BMC neurology · 2014Article
- ANCA-associated Vasculitis in a Case of Congenital Leptin Deficiency.Indian journal of dermatologyArticle
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe current markers of disease activity in Takayasu arteritis (TA) are insufficient for proper assessment. We investigated circulating levels of unacylated and acylated ghrelin, leptin and adiponectin and their relationships with disease activity in patients with TA.
methodsThis study included 31 patients with TA and 32 sex-, age- and body mass index-matched healthy controls. Disease activity was assessed in TA patients using various tools, including Kerr's criteria, disease extent index-Takayasu, physician's global assessment, radiological parameters, and laboratory markers. Plasma unacylated and acylated ghrelin, and serum leptin and adiponectin levels were measured using an enzyme-linked immunosorbent assay.
resultsUnacylated and acylated ghrelin levels were found to be significantly lower in TA patients than that in healthy controls. Patients with active disease had lower unacylated ghrelin levels than those with inactive disease and had lower acylated ghrelin levels than healthy controls. Ghrelin levels were negatively correlated with various parameters of disease activity. The leptin/ghrelin ratio was significantly higher in TA patients than controls. It was positively correlated with disease activity. There was a positive correlation between unacylated and acylated ghrelin and a negative correlation between leptin and ghrelin. There was no statistical difference in adiponectin levels between TA patients and controls. The radiological activity markers were positively correlated with other parameters of disease activity.
conclusionsThis study suggests that plasma unacylated and acylated ghrelin levels may be useful in monitoring disease activity and planning treatment strategies for patients with TA. The serum leptin level and leptin/ghrelin ratio may also be used to help assess the disease activity.
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