ArticleNucleic acids research2013
AT-rich sequence elements promote nascent transcript cleavage leading to RNA polymerase II termination.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Regulation of RNA transcript elongation in metazoans and its relevance to disease.Nature reviews. Molecular cell biology · 2026Review
- Termination sequence between an inducible promoter and ubiquitous chromatin opening element (UCOE) reduces gene expression leakage and silencing.Journal of biological engineering · 2025Article
- DNA-directed termination of mammalian RNA polymerase II.Genes & development · 2024Article
- DNA-directed termination of RNA polymerase II transcription.Molecular cell · 2023Article
- Post-transcriptional polyadenylation site cleavage maintains 3'-end processing upon DNA damage.The EMBO journal · 2023Article
- Screening thousands of transcribed coding and non-coding regions reveals sequence determinants of RNA polymerase II elongation potential.Nature structural & molecular biology · 2022Article
- Control of Multigene Expression Stoichiometry in Mammalian Cells Using Synthetic Promoters.ACS synthetic biology · 2021Article
- Fine gene expression regulation by minor sequence variations downstream of the polyadenylation signal.Molecular biology reports · 2021Article
- BRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair.Molecular cell · 2015Article
- Manipulating archaeal systems to permit analyses of transcription elongation-termination decisions in vitro.Methods in molecular biology (Clifton, N.J.) · 2015Article
- Terminate and make a loop: regulation of transcriptional directionality.Trends in biochemical sciences · 2014Review
- Article
- Splicing-coupled 3' end formation requires a terminal splice acceptor site, but not intron excision.Nucleic acids research · 2013Article
- Article
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Authors and funding
4 authors.
Funding
Abstract
RNA Polymerase II (Pol II) termination is dependent on RNA processing signals as well as specific terminator elements located downstream of the poly(A) site. One of the two major terminator classes described so far is the Co-Transcriptional Cleavage (CoTC) element. We show that homopolymer A/T tracts within the human β-globin CoTC-mediated terminator element play a critical role in Pol II termination. These short A/T tracts, dispersed within seemingly random sequences, are strong terminator elements, and bioinformatics analysis confirms the presence of such sequences in 70% of the putative terminator regions (PTRs) genome-wide.
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Registered trials
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