Evidence map›Paper›PMID 23258569›Full record

ArticleAutism research : official journal of the International Society for Autism Research2013

Exploring the relationship between anxiety and insistence on sameness in autism spectrum disorders.

Katherine Gotham, Somer L Bishop, Vanessa Hus, Marisela Huerta, Sabata Lund, Andreas Buja, Abba Krieger, Catherine Lord

Open access · bronzeAbstract read
In one paragraph

Article in Autism research : official journal of the International Society for Autism Research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 7 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 7 syntheses or guidelines pooled it, 180 citations in OpenAlex.

  1. Pooled it
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  4. IQ and Internalising Symptoms in Adolescents with ASD.Journal of autism and developmental disorders · 2021
    Pooled it
  5. Anxiety and intellectual functioning in autistic children: A systematic review and meta-analysis.Autism : the international journal of research and practice · 2021
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Katherine GothamVanderbilt Kennedy Center, Nashville, TN, USA. katherine.gotham@vanderbilt.edu
Somer L Bishop
Vanessa Hus
Marisela Huerta
Sabata Lund
Andreas Buja
Abba Krieger
Catherine Lord
Michigan United · USNew York Hospital Queens · USUniversity of Michigan–Ann Arbor · USUniversity of Pennsylvania · USUniversity of the Arts · USVanderbilt Health · US

Funding

THREE-TIERED PREVENTION MODEL TO BETTER SERVE ALL STUDENP30HD015052 · NICHD · VANDERBILT UNIVERSITY · PI DYKENS, ELISABETH MAY · 1985 to 2014
$18.6M
LIFE-SPAN DEVELOPMENT OF NORMAL AND ABNORMAL BEHAVIORT32MH018921 · NIMH · VANDERBILT UNIVERSITY · PI HUMPHREYS, KATHRYN LEIGH · 1989 to 2024
$6.7M
Longitudinal Studies of Autism Spectrum Disorders: 2 to 23R01MH081873 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI LORD, CATHERINE · 2008 to 2012
$2.7M
1/2 Development of a Screening Interview for Research Studies of ASDR01MH089390 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MONK, CHRISTOPHER STEPHEN · 2009 to 2010
$1.3M
Development of a Brief Screener for Research in Autism Spectrum DisordersRC1MH089721 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MONK, CHRISTOPHER STEPHEN · 2009 to 2010
$997k
2/2 Development of a Screening Interview for Research Studies of ASDR01HD065277 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI BISHOP, SOMER L. · 2009 to 2010
$737k
NICHD NIH HHS P30 HD015052NICHD NIH HHS P30HD15052NICHD NIH HHS R01 HD065277NICHD NIH HHS R01HD065277NIMH NIH HHS R01 MH081873NIMH NIH HHS R01MH081873-01A1NIMH NIH HHS R01 MH089390NIMH NIH HHS RC1 MH089721NIMH NIH HHS RC1MH089721NIMH NIH HHS T32 MH018921NIMH NIH HHS T32-MH18921
6 · The paper itself

Abstract

Elevated anxiety symptoms are one of the most common forms of psychopathology to co-occur with autism spectrum disorders (ASDs). The purpose of this study was to explore the association between anxiety and ASD symptoms, particularly the degree to which the relationship is explained by insistence on sameness (IS) behaviors and/or cognitive ability. The sample included 1429 individuals aged 5:8-18:0 years who participated in the Simons Simplex Collection, a genetic consortium study of ASD. Child Behavior Checklist Anxiety Problems T-scores and Autism Diagnostic Interview-Revised "IS" item raw totals were treated as both categorical and continuous measures of anxiety and IS, respectively. Chronological age, verbal intelligence quotient (IQ), and a variety of ASD phenotype-related and other behavioral variables were assessed for potential association with anxiety and IS. Anxiety and IS continuous variables were minimally, although significantly, associated with each other and with chronological age and verbal IQ. Neither anxiety nor IS was associated with other core autism diagnostic scores. Anxiety was associated with a variety of other psychiatric and behavioral symptoms in ASD, including irritability, attention problems, and aggression, while IS was not. Anxiety and IS appear to function as distinct constructs, each with a wide range of expression in children with ASD across age and IQ levels. Thus, both variables could be of use in ASD behavioral research or in dimensional approaches to genetic exploration. Unlike IS, however, anxiety is related to non-ASD-specific behavioral symptoms.

Indexed as

AdolescentAnxiety DisordersChildChild BehaviorChild Development Disorders, PervasiveChild, PreschoolFemaleHumansIntelligenceLongitudinal StudiesMale

Identifiers

PMID23258569
PMCPMC4373663
OpenAlexW1800315463

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.