ArticleInternational journal of oral science2012
Dentin matrix protein 1 and phosphate homeostasis are critical for postnatal pulp, dentin and enamel formation.
Article in International journal of oral science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Spatial Regulation of Preameloblast Development in Response to Distal Mouse Incisor Injury.Calcified tissue international · 2026Article
- Phosphate: An Anion Controlling Metabolic Functions.Nutrients · 2026Review
- Article
- Decoding dental mesenchymal stem cells diversity: single-cell transcriptomics maps heterogeneity in molar development.Frontiers in cell and developmental biology · 2025Review
- Injectable CNPs/DMP1-loaded self-assembly hydrogel regulating inflammation of dental pulp stem cells for dentin regeneration.Materials today. Bio · 2024Article
- Dental manifestations and treatment of hypophosphatemic rickets: A case report and review of literature.BDJ open · 2023Article
- The phosphorylation of serineMatrix biology : journal of the International Society for Matrix Biology · 2022Article
- Odontoblast processes of the mouse incisor are plates oriented in the direction of growth.Anatomical record (Hoboken, N.J. : 2007) · 2021Article
- Role of Cell Death in Cellular Processes During Odontogenesis.Frontiers in cell and developmental biology · 2021Review
- Dentinogenesis and Tooth-Alveolar Bone Complex Defects inStem cells and development · 2019Article
- Conditional Knockout of Raptor/mTORC1 Results in Dentin Malformation.Frontiers in physiology · 2019Article
- Hyperphosphatemic familial tumoral calcinosis secondary to fibroblast growth factor 23 (FGF23) mutation: a report of two affected families and review of the literature.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Review
- Critical roles of periostin in the process of orthodontic tooth movement.European journal of orthodontics · 2016Article
- FGF23 neutralization improves bone quality and osseointegration of titanium implants in chronic kidney disease mice.Scientific reports · 2015Article
- Human Umbilical Cord Mesenchymal Stem Cells: A New Therapeutic Option for Tooth Regeneration.Stem cells international · 2015Article
- Adipogenic differentiation potential of adipose-derived mesenchymal stem cells from ovariectomized mice.Cell proliferation · 2014Article
- Osteogenic differentiation of adipose-derived stem cells promoted by quercetin.Cell proliferation · 2014Article
- BMP4 promotes vascularization of human adipose stromal cells and endothelial cells in vitro and in vivo.Cell proliferation · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Deletion or mutation of dentin matrix protein 1 (DMP1) leads to hypophosphatemic rickets and defects within the dentin. However, it is largely unknown if this pathological change is a direct role of DMP1 or an indirect role of phosphate (Pi) or both. It has also been previously shown that Klotho-deficient mice, which displayed a high Pi level due to a failure of Pi excretion, causes mild defects in the dentinal structure. This study was to address the distinct roles of DMP1 and Pi homeostasis in cell differentiation, apoptosis and mineralization of dentin and enamel. Our working hypothesis was that a stable Pi homeostasis is critical for postnatal tooth formation, and that DMP1 has an antiapoptotic role in both amelogenesis and dentinogenesis. To test this hypothesis, Dmp1-null (Dmp1(-/-)), Klotho-deficient (kl/kl), Dmp1/Klotho-double-deficient (Dmp1(-/-)/kl/kl) and wild-type (WT) mice were killed at the age of 6 weeks. Combinations of X-ray, microcomputed tomography (μCT), scanning electron microscopy (SEM), histology, apoptosis and immunohistochemical methods were used for characterization of dentin, enamel and pulp structures in these mutant mice. Our results showed that Dmp1(-/-) (a low Pi level) or kl/kl (a high Pi level) mice displayed mild dentin defects such as thin dentin and a reduction of dentin tubules. Neither deficient mouse line exhibited any apparent changes in enamel or pulp structure. However, the double-deficient mice (a high Pi level) displayed severe defects in dentin and enamel structures, including loss of dentinal tubules and enamel prisms, as well as unexpected ectopic ossification within the pulp root canal. TUNEL assay showed a sharp increase in apoptotic cells in ameloblasts and odontoblasts. Based on the above findings, we conclude that DMP1 has a protective role for odontoblasts and ameloblasts in a pro-apoptotic environment (a high Pi level).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.