ReviewCell adhesion & migration
VEGF levels and the angiogenic potential of the microenvironment can affect surgical strategy for colorectal liver metastasis.
Review in Cell adhesion & migration. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Endothelial Progenitor Cells Promote Osteosarcoma Progression and Invasiveness via AKT/PI3K Signaling.Cancers · 2023Article
- Disappearing Colorectal Liver Metastases: Do We Really Need a Ghostbuster?Healthcare (Basel, Switzerland) · 2022Review
- Surgery on primary tumor shows survival benefit in selected stage IV colon cancer patients: A real-world study based on SEER database.Journal of Cancer · 2020Article
- In-Depth Characterization of Mass Spectrometry-Based Proteomic Profiles Revealed Novel Signature Proteins Associated with Liver Metastatic Colorectal Cancers.Analytical cellular pathology (Amsterdam) · 2019Article
- Chitosan oligosaccharides in combination with Agaricus blazei Murill extract reduces hepatoma formation in mice with severe combined immunodeficiency.Molecular medicine reports · 2015Article
- Hallmarks in colorectal cancer: angiogenesis and cancer stem-like cells.World journal of gastroenterology · 2014Review
- Potential role of High mobility group box 1 in hepatocellular carcinoma.Cell adhesion & migration · 2014Review
- Targeting angiogenesis and tumor microenvironment in metastatic colorectal cancer: role of aflibercept.Gastroenterology research and practice · 2014Review
- Interleukin-12 prevents colorectal cancer liver metastases in mice.OncoTargets and therapy · 2013Article
- VEGF isoforms.Cell adhesion & migrationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hypotheses emerging from basic research on colorectal liver metastases must be tested in clinical situations for the adaptation of current treatment strategies. Pre-metastatic niches have been shown to exist in human colorectal synchronous metastases, with the liver parenchyma adjacent to the synchronous liver metastases providing a favorable, angiogenic environment for metastatic tumor growth. The role of the VEGF signaling pathway in liver regeneration and tumor growth remains unclear, but the use of antiangiogenic agents in combination with surgical treatment is almost certainly beneficial.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.