ArticlePhysics in medicine and biology2013
The effect of temporal impulse response on experimental reduction of photon scatter in time-resolved diffuse optical tomography.
Article in Physics in medicine and biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Assessment of Gate Width Size on Lifetime-Based Förster Resonance Energy Transfer Parameter Estimation.Photonics · 2015Article
- Fast single photon avalanche photodiode-based time-resolved diffuse optical tomography scanner.Biomedical optics express · 2015Article
- An extended analytical approach for diffuse optical imaging.Physics in medicine and biology · 2015Article
- Fast reconstruction of 3D volumes from 2D CT projection data with GPUs.BMC research notes · 2014Article
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4 authors.
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Abstract
New fast detector technology has driven significant renewed interest in time-resolved measurement of early photons in improving imaging resolution in diffuse optical tomography and fluorescence mediated tomography in recent years. In practice, selection of early photons results in significantly narrower instrument photon density sensitivity functions (PDSFs) than the continuous wave case, resulting in a better conditioned reconstruction problem. In this work, we studied the quantitative impact of the instrument temporal impulse response function (TIRF) on experimental PDSFs in tissue mimicking optical phantoms. We used a multimode fiber dispersion method to vary the system TIRF over a range of representative literature values. Substantial disagreement in PDSF width--by up to 40%--was observed between experimental measurements and Monte Carlo (MC) models of photon propagation over the range of TIRFs studied. On average, PDSFs were broadened by about 0.3 mm at the center plane of the 2 cm wide imaging chamber per 100 ps of the instrument TIRF at early times. Further, this broadening was comparable on both the source and detector sides. Results were confirmed by convolution of instrument TIRFs with MC simulations. These data also underscore the importance of correcting imaging PDSFs for the instrument TIRF when performing tomographic image reconstruction to ensure accurate data-model agreement.
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