ArticleNeurobiology of learning and memory2013
Context-specific effects of estradiol on spatial learning and memory in the zebra finch.
Article in Neurobiology of learning and memory, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- What do zebra finches learn besides singing? Systematic mapping of the literature and presentation of an efficient associative learning test.Animal cognition · 2023Pooled it
- Auditory learning in an operant task with social reinforcement is dependent on neuroestrogen synthesis in the male songbird auditory cortex.Hormones and behavior · 2020Article
- Neuroestrogen synthesis modifies neural representations of learned song without altering vocal imitation in developing songbirds.Scientific reports · 2020Article
- Acute neuroestrogen blockade attenuates song-induced immediate early gene expression in auditory regions of male and female zebra finches.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Article
- Neuroestrogens rapidly shape auditory circuits to support communication learning and perception: Evidence from songbirds.Hormones and behavior · 2018Review
- On the role of brain aromatase in females: why are estrogens produced locally when they are available systemically?Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Review
- Cognitive Effects of Aromatase and Possible Role in Memory Disorders.Frontiers in endocrinology · 2018Review
- Across sex and age: Learning and memory and patterns of avian hippocampal gene expression.Behavioral neuroscience · 2017Article
- Hippocampal Aromatization Modulates Spatial Memory and Characteristics of the Synaptic Membrane in the Male Zebra Finch.Endocrinology · 2017Article
- The importance of studying sex differences in disease: The example of multiple sclerosis.Journal of neuroscience research · 2017Review
- Inhibition of local estrogen synthesis in the hippocampus impairs hippocampal memory consolidation in ovariectomized female mice.Hormones and behavior · 2016Article
- Brain estrogen production and the encoding of recent experience.Current opinion in behavioral sciences · 2015Article
- Steroids in the Avian Brain: Heterogeneity across Space and Time.Journal of ornithology · 2015Article
- Sex, estradiol, and spatial memory in a food-caching corvid.Hormones and behavior · 2015Article
- The importance of neural aromatization in the acquisition, recall, and integration of song and spatial memories in passerines.Hormones and behavior · 2015Review
- Dynamic variation in forebrain estradiol levels during song learning.Developmental neurobiology · 2015Article
- Establishing regional specificity of neuroestrogen action.General and comparative endocrinology · 2014Article
- Inhibition of hippocampal aromatization impairs spatial memory performance in a male songbird.Endocrinology · 2013Article
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4 authors at 1 institution in 1 country.
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Abstract
Estradiol is known to impact cognitive function including spatial learning and memory, with studies focused largely on rodent models. Estrogens can be produced peripherally or centrally as neuroestrogens, and the specific role for neuroestrogens in memory processes remains unresolved. Many songbirds possess remarkable spatial memory capabilities and also express the estrogen synthetic enzyme aromatase abundantly in the hippocampus, suggesting that locally-produced estrogens may promote the acquisition or retrieval of spatial memories in these birds. We examined the effect of estradiol on spatial memory in three contexts in the zebra finch: retrieval after discrimination training, retrieval after familiarization but without discrimination training, and memory acquisition, using a combination of estradiol implants and oral dosing with the aromatase inhibitor fadrozole (FAD). Retrieval of spatial memory in both contexts was impaired when estradiol production was blocked. However, spatial memory acquisition was enhanced when estradiol production was inhibited whereas estradiol replacement impaired acquisition. These results provide evidence for a context-specific role of estradiol in songbird spatial memory, results that find accord with some mammalian studies but have not yet been observed in birds.
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