ArticleBMC genomics2012
MicroRNAs and essential components of the microRNA processing machinery are not encoded in the genome of the ctenophore Mnemiopsis leidyi.
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Pooled it
- Dicer structure and function: conserved and evolving features.EMBO reports · 2023Review
- Small RNAs in Cnidaria: A review.Evolutionary applications · 2023Article
- Multigenerational laboratory culture of pelagic ctenophores and CRISPR-Cas9 genome editing in the lobate Mnemiopsis leidyi.Nature protocols · 2022Review
- Diverse RNA interference strategies in early-branching metazoans.BMC evolutionary biology · 2018Article
- Unicellular Origin of the Animal MicroRNA Machinery.Current biology : CB · 2018Article
- Plant epigenetic mechanisms: role in abiotic stress and their generational heritability.3 Biotech · 2018Review
- The maternal-zygotic transition and zygotic activation of the Mnemiopsis leidyi genome occurs within the first three cleavage cycles.Molecular reproduction and development · 2017Article
- The evolutionary origin of plant and animal microRNAs.Nature ecology & evolution · 2017Article
- An Improved microRNA Annotation of the Canine Genome.PloS one · 2016Article
- The miRNA biogenesis in marine bivalves.PeerJ · 2016Article
- KLF/SP Transcription Factor Family Evolution: Expansion, Diversification, and Innovation in Eukaryotes.Genome biology and evolution · 2015Article
- SubmiRine: assessing variants in microRNA targets using clinical genomic data sets.Nucleic acids research · 2015Article
- Review
- Reconsidering the phylogenetic utility of miRNA in animals.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Evolutionary biology: Excitation over jelly nerves.Nature · 2014Article
- A customized Web portal for the genome of the ctenophore Mnemiopsis leidyi.BMC genomics · 2014Article
- Article
- The evolution of microRNA pathway protein components in Cnidaria.Molecular biology and evolution · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundMicroRNAs play a vital role in the regulation of gene expression and have been identified in every animal with a sequenced genome examined thus far, except for the placozoan Trichoplax. The genomic repertoires of metazoan microRNAs have become increasingly endorsed as phylogenetic characters and drivers of biological complexity.
resultsIn this study, we report the first investigation of microRNAs in a species from the phylum Ctenophora. We use short RNA sequencing and the assembled genome of the lobate ctenophore Mnemiopsis leidyi to show that this species appears to lack any recognizable microRNAs, as well as the nuclear proteins Drosha and Pasha, which are critical to canonical microRNA biogenesis. This finding represents the first reported case of a metazoan lacking a Drosha protein.
conclusionsRecent phylogenomic analyses suggest that Mnemiopsis may be the earliest branching metazoan lineage. If this is true, then the origins of canonical microRNA biogenesis and microRNA-mediated gene regulation may postdate the last common metazoan ancestor. Alternatively, canonical microRNA functionality may have been lost independently in the lineages leading to both Mnemiopsis and the placozoan Trichoplax, suggesting that microRNA functionality was not critical until much later in metazoan evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.