ArticleJournal of proteome research2013
Quantitative peptidomics for discovery of circadian-related peptides from the rat suprachiasmatic nucleus.
Article in Journal of proteome research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 57 citations in OpenAlex.
- Biological Fluid Flows: Signaling Mediums for Circadian Timing.Journal of biological rhythms · 2025Review
- The physiological and pathophysiological roles of copper in the nervous system.The European journal of neuroscience · 2024Review
- Label-Free Quantitation of Endogenous Peptides.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Microanalytical Mass Spectrometry with Super-Resolution Microscopy Reveals a Proteome Transition During Development of the Brain's Circadian Pacemaker.Analytical chemistry · 2023Article
- Developmental patterning of peptide transcription in the central circadian clock in both sexes.Frontiers in neuroscience · 2023Article
- Alternative Splicing of Neuropeptide Prohormone and Receptor Genes Associated with Pain Sensitivity Was Detected with Zero-Inflated Models.Biomedicines · 2022Article
- Atomic view of an amyloid dodecamer exhibiting selective cellular toxic vulnerability in acute brain slices.Protein science : a publication of the Protein Society · 2022Article
- Identification of the suprachiasmatic nucleus venous portal system in the mammalian brain.Nature communications · 2021Article
- Seasonality and light phase-resetting in the mammalian circadian rhythm.Scientific reports · 2020Article
- Dual-Color Single-Cell Imaging of the Suprachiasmatic Nucleus Reveals a Circadian Role in Network Synchrony.Neuron · 2020Article
- Ion Channels Controlling Circadian Rhythms in Suprachiasmatic Nucleus Excitability.Physiological reviews · 2020Review
- Thimet Oligopeptidase Biochemical and Biological Significances: Past, Present, and Future Directions.Biomolecules · 2020Review
- Vasopressin in circadian function of SCN.Journal of biosciences · 2020Review
- Strategies for the Identification of Bioactive Neuropeptides in Vertebrates.Frontiers in neuroscience · 2019Review
- Exploring Exercise- and Context-Induced Peptide Changes in Mice by Quantitative Mass Spectrometry.ACS omega · 2018Article
- Functional Peptidomics: Stimulus- and Time-of-Day-Specific Peptide Release in the Mammalian Circadian Clock.ACS chemical neuroscience · 2018Article
- Neuropeptidomics of the Rat Habenular Nuclei.Journal of proteome research · 2018Article
- Mapping Molecular Datasets Back to the Brain Regions They are Extracted from: Remembering the Native Countries of Hypothalamic Expatriates and Refugees.Advances in neurobiology · 2018Article
- Improved identification and quantitation of mature endogenous peptides in the rodent hypothalamus using a rapid conductive sample heating system.The Analyst · 2017Article
- Quantitative Mass Spectrometry Reveals Food Intake-Induced Neuropeptide Level Changes in Rat Brain: Functional Assessment of Selected Neuropeptides as Feeding Regulators.Molecular & cellular proteomics : MCP · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
In mammals the suprachiasmatic nucleus (SCN), the master circadian clock, is sensitive to light input via the optic chiasm and synchronizes many daily biological rhythms. Here we explore variations in the expression levels of neuropeptides present in the SCN of rats using a label-free quantification approach that is based on integrating peak intensities between daytime, Zeitgeber time (ZT) 6, and nighttime, ZT 18. From nine analyses comparing the levels between these two time points, 10 endogenous peptides derived from eight prohormones exhibited significant differences in their expression levels (adjusted p-value <0.05). Of these, seven peptides derived from six prohormones, including GRP, PACAP, and CART, exhibited ≥ 30% increases at ZT 18, and the VGRPEWWMDYQ peptide derived from proenkephalin A showed a >50% increase at nighttime. Several endogenous peptides showing statistically significant changes in this study have not been previously reported to alter their levels as a function of time of day, nor have they been implicated in prior functional SCN studies. This information on peptide expression changes serves as a resource for discovering unknown peptide regulators that affect circadian rhythms in the SCN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.