ArticleRetrovirology2012
Wip1 and p53 contribute to HTLV-1 Tax-induced tumorigenesis.
Article in Retrovirology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Review
- The role of viruses in cancer development versus cancer therapy: An oncological perspective.Cancer medicine · 2023Review
- Article
- Clinical significance of TP53 mutations in adult T-cell leukemia/lymphoma.British journal of haematology · 2021Article
- In Vivo Tumorigenesis, Osteolytic Sarcomas, and Tumorigenic Cell Lines from Transgenic Mice Expressing the Human T-Lymphotropic Virus Type 1 (HTLV-1) Tax Viral Oncogene.The American journal of pathology · 2021Article
- Global expression of noncoding RNome reveals dysregulation of small RNAs in patients with HTLV-1-associated adult T-cell leukemia: a pilot study.Infectious agents and cancer · 2021Article
- Autophagy Modulation by Viral Infections Influences Tumor Development.Frontiers in oncology · 2021Review
- Small cells lung epidermoid carcinoma in a HTLV1-infected patient: case report and literature review.Revista do Instituto de Medicina Tropical de Sao Paulo · 2021Review
- Potentiality of Protein phosphatase MgJournal of clinical laboratory analysis · 2020Article
- Silencers of HTLV-1 and HTLV-2: the pX-encoded latency-maintenance factors.Retrovirology · 2019Review
- Article
- Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.Cancers · 2018Review
- The human T-cell leukemia virus type-1 p30Virology · 2018Article
- Molecular Studies of HTLV-1 Replication: An Update.Viruses · 2016Review
- How does HTLV-1 cause adult T-cell leukaemia/lymphoma (ATL)?Current opinion in virology · 2015Review
- Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence.Viruses · 2015Review
- Article
- A novel one-class SVM based negative data sampling method for reconstructing proteome-wide HTLV-human protein interaction networks.Scientific reports · 2015Article
- Human viral oncogenesis: a cancer hallmarks analysis.Cell host & microbe · 2014Review
- Ring finger protein 39 genetic variants associate with HIV-1 plasma viral loads and its replication in cell culture.Cell & bioscience · 2014Article
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9 authors.
Funding
Abstract
backgroundHuman T-cell Leukemia Virus type 1 (HTLV-1) infects 20 million individuals world-wide and causes Adult T-cell Leukemia/Lymphoma (ATLL), a highly aggressive T-cell cancer. ATLL is refractory to treatment with conventional chemotherapy and fewer than 10% of afflicted individuals survive more than 5 years after diagnosis. HTLV-1 encodes a viral oncoprotein, Tax, that functions in transforming virus-infected T-cells into leukemic cells. All ATLL cases are believed to have reduced p53 activity although only a minority of ATLLs have genetic mutations in their p53 gene. It has been suggested that p53 function is inactivated by the Tax protein.
resultsUsing genetically altered mice, we report here that Tax expression does not achieve a functional equivalence of p53 inactivation as that seen with genetic mutation of p53 (i.e. a p53 -/- genotype). Thus, we find statistically significant differences in tumorigenesis between Tax+p53 +/+ versus Tax+p53 -/- mice. We also find a role contributed by the cellular Wip1 phosphatase protein in tumor formation in Tax transgenic mice. Notably, Tax+Wip1 -/- mice show statistically significant reduced prevalence of tumorigenesis compared to Tax+Wip1 +/+ counterparts.
conclusionsOur findings provide new insights into contributions by p53 and Wip1 in the in vivo oncogenesis of Tax-induced tumors in mice.
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