ArticleOncology letters2013
Rapamycin induces autophagy in the melanoma cell line M14 via regulation of the expression levels of Bcl-2 and Bax.
Article in Oncology letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Autophagy as a targeted therapeutic approach for skin cancer: Evaluating natural and synthetic molecular interventions.Cancer pathogenesis and therapy · 2024Review
- Schisandrin B attenuates bleomycin-induced pulmonary fibrosis in mice through AKT-mTOR pathway.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2024Article
- Melanoma therapeutics: a literature review.Journal of biomedical research · 2022Article
- Nanoparticle-Based Combination Therapy for Melanoma.Frontiers in oncology · 2022Review
- Novel Nanoliposomes Alleviate Contrast-Induced Nephropathy by Mediating Apoptosis Response in New Zealand Rabbits.Frontiers in molecular biosciences · 2021Article
- Rapamycin Treatment of Tendon Stem/Progenitor Cells Reduces Cellular Senescence by Upregulating Autophagy.Stem cells international · 2021Article
- Berberine attenuates mitochondrial dysfunction by inducing autophagic flux in myocardial hypoxia/reoxygenation injury.Cell stress & chaperones · 2020Article
- Apoptosis gene reprograming of human peripheral blood mononuclear cells induced by radioiodine-131 (The Indian journal of medical research · 2019Article
- The Anti-proliferative Activity of GnRH Through Downregulation of the Akt/ERK Pathways in Pancreatic Cancer.Frontiers in endocrinology · 2019Article
- ROS-induced autophagy reduces B16F10 melanoma cell proliferative activity.Lasers in medical science · 2018Article
- Iron(III)-Tannic Molecular Nanoparticles Enhance Autophagy effect and TScientific reports · 2018Article
- Melanoma treatment in review.ImmunoTargets and therapy · 2018Review
- JNK pathway mediates curcumin-induced apoptosis and autophagy in osteosarcoma MG63 cells.Experimental and therapeutic medicine · 2017Article
- Intra-articular injection of Torin 1 reduces degeneration of articular cartilage in a rabbit osteoarthritis model.Bone & joint research · 2016Article
- Anti-cancer Effect of Luminacin, a Marine Microbial Extract, in Head and Neck Squamous Cell Carcinoma Progression via Autophagic Cell Death.Cancer research and treatment · 2016Article
- Ultrastructural analysis of different human mesenchymal stem cells after in vitro expansion: a technical review.European journal of histochemistry : EJH · 2015Article
- Rapamycin Promotes Mouse 4T1 Tumor Metastasis that Can Be Reversed by a Dendritic Cell-Based Vaccine.PloS one · 2015Article
- mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis.PloS one · 2015Article
- Ciclopirox induces autophagy through reactive oxygen species-mediated activation of JNK signaling pathway.Oncotarget · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer therapy with rapamycin has been successfully implemented for kidney cancer, glioblastoma and prostate cancer. However, there are few studies concerning the effects of rapamycin on the treatment of human melanoma. In this study, we investigated whether rapamycin may be a promising strategy for the effective treatment of melanoma and explored the possible mechanism for this by culturing M14 cells in vitro and treating with rapamycin at three concentrations (10, 50 or 100 nmol/l). MDC and LC3B staining, western blot analysis, flow cytometry and transmission electron microscopy were employed. We revealed that rapamycin induced autophagy and inhibited the proliferation of M14 cells in a concentration-dependent manner, Furthermore, western blot analysis revealed an upregulated expression of Bcl-2 and downregulated expression of Bax in M14 cells. In conclusion, rapamycin induced autophagy and inhibited the growth of M14 cells. The mechanism may involve regulation of the expression of Bcl-2 family proteins. Rapamycin appears to be a promising strategy for the effective treatment of melanoma.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.