ArticleOncology letters2013
Superficial spreading squamous cell carcinoma of the uterine cervix involving the endometrium: Report of two cases with emphasis on the likely molecular mechanism.
Article in Oncology letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Uterine squamous cell carcinoma in a 10-year-old Vietnamese pot-bellied pig (Sus scrofa domesticus).BMC veterinary research · 2026Article
- MRI in deciphering the superficial spread of cervical squamous cell carcinoma into the uterine corpus: A case report and literature review.Oncoscience · 2026Article
- Superficial spreading squamous cell carcinoma of the cervix involving the endometrium: A case report and literature review.Experimental and therapeutic medicine · 2025Article
- Rare widespread dissemination of cervical high-grade squamous intraepithelial lesion with microinvasive squamous cell carcinoma: a case report.Frontiers in oncology · 2025Article
- Superficial Spread of Nonkeratinizing Squamous Cell Carcinoma of the Cervix to the Endometrium: A Case Report.Cureus · 2024Article
- An unusual pattern of endometrial involvement: superficial spreading squamous cell carcinoma of the cervix.Frontiers in oncology · 2024Article
- Curious Case of Superfitial Spreading Cervical Squamocellular Carcinoma with Adnexal Involvement.Medicina (Kaunas, Lithuania) · 2022Article
- Endometrial squamous cell carcinoma originating from the cervix: A case report.World journal of clinical cases · 2022Article
- Superficial spreading cervical squamous cell carcinoma in situ involving the endometrium: a case report and review of the literature.Journal of medical case reports · 2022Review
- A review and case report of enigmatic superficial endometrial spread of cancer of the uterine cervix: Need for vigilance in the primary care setting.Journal of family medicine and primary care · 2021Article
- Superficial spreading squamous cell carcinoma in situ of the cervix involving the endometrium: a rare case presentation and review of literature.International journal of clinical and experimental pathology · 2019Article
- Primary Endometrial Squamous Cell Carcinoma In Situ: Report of a rare disease.Sultan Qaboos University medical journal · 2015Article
- Unusual Extension of Superficial Spreading Squamous Cell Carcinoma of Cervix to Uterus, Paraovarian, Paratubal Tissue, and Vaginal Surface: A Unique Case Report.Journal of mid-life healthArticle
- Squamous Cell CarcinomaIndian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric OncologyArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Squamous cell carcinoma (SCC) of the cervix generally invades directly into the uterine wall, but in rare cases it spreads superficially to the inner surface of the uterus, thereby replacing the endometrium. This type is called superficial spreading SCC. In the present study we report two cases of this unusual form of cervical SCC and discuss the possible molecular mechanism involved. Two females, aged 64 (case 1) and 59 (case 2) years old, presented with post-menopausal vaginal bleeding. Histopathological studies of the resected specimens revealed non-keratinizing SCC of the cervix (pTIIA1 in case 1 and pTIIB in case 2). A notable finding in the two tumors was that atypical squamous cells were extending and replacing the endometrium directly from the cervix. Glandular involvement of atrophic endometrial glands was observed, however no invasive growth was observed in the endometrium in either case. Immunohistochemical studies revealed that CD138 was strongly expressed in the carcinoma cells superficially spreading in the endometrium in the two cases. It has been reported that the loss of expression of CD138, a cell-surface heparan sulfate proteoglycan participating in cell-cell and cell-extracellular matrix interactions, is correlated with tumor invasion and progression to cervical SCC. Our present findings suggest that CD138 expression in carcinoma cells may participate in superficial spread by regulating cell-cell interactions.
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Registered trials
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