ArticleAJR. American journal of roentgenology2013
Characterization of human brown adipose tissue by chemical-shift water-fat MRI.
Article in AJR. American journal of roentgenology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.
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Who cites it
66 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.
- Activation of Human Brown Adipose Tissue by Capsinoids, Catechins, Ephedrine, and Other Dietary Components: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2019Pooled it
- Meal-Induced Proton Density Fat Fraction andNMR in biomedicine · 2026Article
- Chemical Shift Separated and Compensated Ultra-Short Echo-Time Imaging.Magnetic resonance in medicine · 2026Article
- Quantitative MRI of lipid content for assessing fetal adipose tissue development and brown-to-white fat conversion.Insights into imaging · 2026Article
- Integrating Magnetic Resonance Chemical Shift Imaging for Localized Prostate Cancer Risk Stratification on the Basis of the Impact of Periprostatic Brown Adipocytes Within Tumor Microenvironment.Annals of surgical oncology · 2025Article
- Intraindividual difference between supraclavicular and subcutaneous proton density fat fraction is associated with cold-induced thermogenesis.Quantitative imaging in medicine and surgery · 2022Article
- Quantification of brown adipose tissueQuantitative imaging in medicine and surgery · 2022Article
- Practical application of in vivo MRI-based brown adipose tissue measurements in infants.Obesity (Silver Spring, Md.) · 2021Article
- Brown Adipose Tissue, Adiposity, and Metabolic Profile in Preschool Children.The Journal of clinical endocrinology and metabolism · 2021Article
- Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota.Cell reports. Medicine · 2021Article
- PET/MRI of glucose metabolic rate, lipid content and perfusion in human brown adipose tissue.Scientific reports · 2021Article
- Water-fat magnetic resonance imaging of adipose tissue compartments in the normal third trimester fetus.Pediatric radiology · 2021Article
- [Comparison ofNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021Article
- Proton MR Spectroscopy Measurements of White and Brown Adipose Tissue in Healthy Humans: Relaxation Parameters and Unsaturated Fatty Acids.Radiology · 2021Article
- Rotator cuff tear degeneration and the role of fibro-adipogenic progenitors.Annals of the New York Academy of Sciences · 2021Review
- Magnetic Resonance Imaging for Drug Development.Advances in experimental medicine and biology · 2021Article
- Imaging of body composition in children.Quantitative imaging in medicine and surgery · 2020Review
- Brown fat activity determined by infrared thermography and thermogenesis measurement using whole body calorimetry (BRIGHT Study).Physiological research · 2020Article
- Investigation of the Relationship between MR-Based Supraclavicular Fat Fraction and Thyroid Hormones.Obesity facts · 2020Article
- MRI Reveals Human Brown Adipose Tissue Is Rapidly Activated in Response to Cold.Journal of the Endocrine Society · 2019Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe purpose of this study was to characterize human brown adipose tissue (BAT) with chemical-shift water-fat MRI and to determine whether trends and differences in fat-signal fractions and T2(*) relaxation times between BAT and white adipose tissue (WAT) are consistently observed postmortem and in vivo in infants, adolescents, and adults. MATERIALS AND
methodsA postmortem body and eight patients were studied. A six-echo spoiled gradient-echo chemical-shift water-fat MRI sequence was performed at 3 T to jointly quantify fat-signal fraction and T2(*) in interscapular-supraclavicular BAT and subcutaneous WAT. To confirm BAT identity, biopsy and histology served as the reference in the postmortem study and PET/CT was used in five of the eight patients who required examination for medical care.
resultsFat-signal fractions and T2(*) times were lower in BAT than in WAT in the postmortem example and in seven of eight patients. With the exception of one case, nominal comparisons between brown and white adipose tissues were statistically significant (p < 0.05). Between subjects, a large range of fat-signal fraction values was observed in BAT but not in WAT.
conclusionWe have shown that fat-signal fractions and T2(*) values jointly derived from chemical-shift water-fat MRI are lower in BAT than in WAT likely because of differences in cellular structures, triglyceride content, and vascularization. The two metrics can serve as complementary biomarkers in the detection of BAT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.