ArticleJournal of neurophysiology2013
Small-conductance Ca2+-activated K+ channels modulate action potential-induced Ca2+ transients in hippocampal neurons.
Article in Journal of neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Forebrain-Specific B-raf Deficiency Reduces NMDA Current and Enhances Small-Conductance CaInternational journal of molecular sciences · 2025Article
- Intracellular Calcium Responses Encode Action Potential Firing in Spinal Cord Lamina I Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Positive Modulation of SK Channel Impedes Neuron-Specific Cytoskeletal Organization and Maturation.Developmental neuroscience · 2020Article
- Genes regulated by SATB2 during neurodevelopment contribute to schizophrenia and educational attainment.PLoS genetics · 2018Article
- Physiological Roles and Therapeutic Potential of CaFrontiers in molecular neuroscience · 2018Review
- Functional coupling of diverse voltage-gated Ca(2+) channels underlies high fidelity of fast dendritic Ca(2+) signals during burst firing.The Journal of physiology · 2016Article
- Article
- Role of small conductance Ca²⁺-activated K⁺ channels in controlling CA1 pyramidal cell excitability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Developmental mapping of small-conductance calcium-activated potassium channel expression in the rat nervous system.The Journal of comparative neurology · 2014Article
- GluN2A and GluN2B subunit-containing NMDA receptors in hippocampal plasticity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Duration differences of corticostriatal responses in striatal projection neurons depend on calcium activated potassium currents.Frontiers in systems neuroscience · 2013Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
In hippocampal pyramidal neurons, voltage-gated Ca(2+) channels open in response to action potentials. This results in elevations in the intracellular concentration of Ca(2+) that are maximal in the proximal apical dendrites and decrease rapidly with distance from the soma. The control of these action potential-evoked Ca(2+) elevations is critical for the regulation of hippocampal neuronal activity. As part of Ca(2+) signaling microdomains, small-conductance Ca(2+)-activated K(+) (SK) channels have been shown to modulate the amplitude and duration of intracellular Ca(2+) signals by feedback regulation of synaptically activated Ca(2+) sources in small distal dendrites and dendritic spines, thus affecting synaptic plasticity in the hippocampus. In this study, we investigated the effect of the activation of SK channels on Ca(2+) transients specifically induced by action potentials in the proximal processes of hippocampal pyramidal neurons. Our results, obtained by using selective SK channel blockers and enhancers, show that SK channels act in a feedback loop, in which their activation by Ca(2+) entering mainly through L-type voltage-gated Ca(2+) channels leads to a reduction in the subsequent dendritic influx of Ca(2+). This underscores a new role of SK channels in the proximal apical dendrite of hippocampal pyramidal neurons.
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