ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2013
High-intensity interval training increases in vivo oxidative capacity with no effect on P(i)→ATP rate in resting human muscle.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Number of Sprint Repetitions in a Sprint Interval Training Session Does Not Moderate Improvements in V̇OScandinavian journal of medicine & science in sports · 2026Pooled it
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- Basal Energetics and Phosphocreatine Recovery Kinetics in Ambulatory Boys With Duchenne Muscular Dystrophy.NMR in biomedicine · 2026Article
- Hypomethylation in promoters of PGC-1α involved in exercise-driven skeletal muscular alterations in old age.Open life sciences · 2024Article
- Effects of muscle damage onNMR in biomedicine · 2022Article
- Adaptive Changes After 2 Weeks of 10-s Sprint Interval Training With Various Recovery Times.Frontiers in physiology · 2018Article
- Do changes in mitochondrial quality contribute to increases in skeletal muscle oxidative capacity following endurance training?The Journal of physiology · 2017Article
- The Physiological Mechanisms of Performance Enhancement with Sprint Interval Training Differ between the Upper and Lower Extremities in Humans.Frontiers in physiology · 2016Article
- Changes in mitochondrial function and mitochondria associated protein expression in response to 2-weeks of high intensity interval training.Frontiers in physiology · 2015Article
- High-intensity interval training alters ATP pathway flux during maximal muscle contractions in humans.Acta physiologica (Oxford, England) · 2014Article
- Gene transfer of arginine kinase to skeletal muscle using adeno-associated virus.Gene therapy · 2014Article
- Effect of age on in vivo oxidative capacity in two locomotory muscles of the leg.Age (Dordrecht, Netherlands) · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Mitochondrial ATP production is vital for meeting cellular energy demand at rest and during periods of high ATP turnover. We hypothesized that high-intensity interval training (HIT) would increase ATP flux in resting muscle (VPi→ATP) in response to a single bout of exercise, whereas changes in the capacity for oxidative ATP production (Vmax) would require repeated bouts. Eight untrained men (27 ± 4 yr; peak oxygen uptake = 36 ± 4 ml·kg(-1)·min(-1)) performed six sessions of HIT (4-6 × 30-s bouts of all-out cycling with 4-min recovery). After standardized meals and a 10-h fast, VPi→ATP and Vmax of the vastus lateralis muscle were measured using phosphorus magnetic resonance spectroscopy at 4 Tesla. Measurements were obtained at baseline, 15 h after the first training session, and 15 h after completion of the sixth session. VPi→ATP was determined from the unidirectional flux between Pi and ATP, using the saturation transfer technique. The rate of phosphocreatine recovery (kPCr) following a maximal contraction was used to calculate Vmax. While kPCr and Vmax were unchanged after a single session of HIT, completion of six training sessions resulted in a ∼14% increase in muscle oxidative capacity (P ≤ 0.004). In contrast, neither a single nor six training sessions altered VPi→ATP (P = 0.74). This novel analysis of resting and maximal high-energy phosphate kinetics in vivo in response to HIT provides evidence that distinct aspects of human skeletal muscle metabolism respond differently to this type of training.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.