ArticleThe British journal of radiology2013
Comparison of iodinated contrast media for the assessment of atherosclerotic plaque attenuation values by CT coronary angiography: observations in an ex vivo model.
Article in The British journal of radiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 20 citations in OpenAlex.
- Intraplaque Myeloperoxidase Activity as Biomarker of Unstable Atheroma and Adverse Clinical Outcomes in Human Atherosclerosis.JACC. Advances · 2023Article
- Pseudo dual-energy CT-derived iodine mapping using single-energy CT data based on a convolution neural network.BJR open · 2023Article
- Organic Compound with Potential for X-ray Imaging Applications.ACS omega · 2021Article
- Contrast enhancement efficacy of iodinated contrast media: Effect of molecular structure on contrast enhancement.European journal of radiology open · 2018Article
- Optimal boundary detection method and window settings for coronary atherosclerotic plaque volume analysis in coronary computed tomography angiography: comparison with intravascular ultrasound.European radiology · 2016Article
- 320-row coronary computed tomography angiography (CCTA) with automatic exposure control (AEC): effect of 100 kV versus 120 kV on image quality and dose exposure.La Radiologia medica · 2016Article
- Quantification of epicardial adipose tissue in coronary calcium score and CT coronary angiography image data sets: comparison of attenuation values, thickness and volumes.The British journal of radiology · 2016Article
- Role of chemokines in promoting instability of coronary atherosclerotic plaques and the underlying molecular mechanism.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2015Article
- Application of 270 mgI/mL Iodinated Contrast Media in Dual-Source Computed Tomography Coronary Artery Imaging.Acta Cardiologica Sinica · 2014Article
- Assessment of dose exposure and image quality in coronary angiography performed by 640-slice CT: a comparison between adaptive iterative and filtered back-projection algorithm by propensity analysis.La Radiologia medica · 2014Article
- Contrast agent bolus tracking with a fixed threshold or a manual fast start for coronary CT angiography.European radiology · 2014Article
- Article
- Tailoring protocols for chest CT applications: when and how?Diagnostic and interventional radiology (Ankara, Turkey)Review
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare the influence of different iodinated contrast media with several dilutions on plaque attenuation in an ex vivo coronary model studied by multislice CT coronary angiography.
methodsIn six ex vivo left anterior descending coronary arteries immersed in oil, CT (slices/collimation 64×0.625 mm, temporal resolution 210 ms, pitch 0.2) was performed after intracoronary injection of a saline solution, and solutions of a dimeric isosmolar contrast medium (Iodixanol 320 mgI ml(-1)) and a monomeric high-iodinated contrast medium (Iomeprol 400 mgI ml(-1)) with dilutions of 1/80 (low concentration), 1/50 (medium concentration), 1/40 (high concentration) and 1/20 (very high concentration). Two radiologists drew regions of interest in the lumen and in calcified and non-calcified plaques for each solution. 29 cross-sections with non-calcified plaques and 32 cross-sections with calcified plaques were evaluated.
resultsBoth contrast media showed different attenuation values within lumen and plaque (p<0.0001). The correlation between lumen and non-calcified plaque values was good (Iodixanol r=0.793, Iomeprol r=0.647). Clustered medium- and high-concentration solutions showed similar plaque attenuation values, signal-to-noise ratios (SNRs) (non-calcified plaque: medium solution SNR 31.3±15 vs 31.4±20, high solution SNR 39.4±17 vs 37.4±22; calcified plaque: medium solution SNR 305.2±133 vs 298.8±132, high solution SNR 323.9±138 vs 293±123) and derived contrast-to-noise ratios (p>0.05).
conclusionDifferently iodinated contrast media have a similar influence on plaque attenuation profiles. ADVANCES IN KNOWLEDGE: Since iodine load affects coronary plaque attenuation linearly, different contrast media may be equally employed for coronary atherosclerotic plaque imaging.
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