ArticleSmall (Weinheim an der Bergstrasse, Germany)2013
Short and long term, in vitro and in vivo correlations of cellular and tissue responses to mesoporous silicon nanovectors.
Article in Small (Weinheim an der Bergstrasse, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Next-generation biomedical nanorobots: active design, intelligent control, and translational opportunities in regenerative and minimally invasive medicine.Journal of nanobiotechnology · 2026Review
- Quantitative Analysis of Porous Silicon Nanoparticles Functionalization byACS biomaterials science & engineering · 2022Article
- Lysyl oxidase engineered lipid nanovesicles for the treatment of triple negative breast cancer.Scientific reports · 2021Article
- Enhanced thermal effect of plasmonic nanostructures confined in discoidal porous silicon particles.RSC advances · 2020Article
- Liposome-Embedding Silicon Microparticle for Oxaliplatin Delivery in Tumor Chemotherapy.Pharmaceutics · 2020Article
- Biomimetic cellular vectors for enhancing drug delivery to the lungs.Scientific reports · 2020Article
- Cell membrane protein functionalization of nanoparticles as a new tumor-targeting strategy.Clinical and translational medicine · 2019Review
- Exosome-like Nanovectors for Drug Delivery in Cancer.Current medicinal chemistry · 2019Review
- Trends towards Biomimicry in Theranostics.Nanomaterials (Basel, Switzerland) · 2018Review
- Biomimetic nanoparticles with enhanced affinity towards activated endothelium as versatile tools for theranostic drug delivery.Theranostics · 2018Article
- Inflammation and Cancer: In Medio Stat Nano.Current medicinal chemistry · 2018Review
- Chlorin e6 Functionalized Theranostic Multistage Nanovectors Transported by Stem Cells for Effective Photodynamic Therapy.ACS applied materials & interfaces · 2017Article
- Biomimetic carriers mimicking leukocyte plasma membrane to increase tumor vasculature permeability.Scientific reports · 2016Article
- The Emerging Role of Nanotechnology in Cell and Organ Transplantation.Transplantation · 2016Review
- One-pot synthesis of pH-responsive hybrid nanogel particles for the intracellular delivery of small interfering RNA.Biomaterials · 2016Article
- Cell source determines the immunological impact of biomimetic nanoparticles.Biomaterials · 2016Article
- A specifically designed nanoconstruct associates, internalizes, traffics in cardiovascular cells, and accumulates in failing myocardium: a new strategy for heart failure diagnostics and therapeutics.European journal of heart failure · 2016Article
- Mechanism of erosion of nanostructured porous silicon drug carriers in neoplastic tissues.Nature communications · 2015Article
- Multistage Nanovectors Enhance the Delivery of Free and Encapsulated Drugs.Current drug targets · 2015Article
- Intravital Microscopy Imaging Approaches for Image-Guided Drug Delivery Systems.Current drug targets · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The characterization of nanomaterials and their influence on and interactions with the biology of cells and tissues are still partially unknown. Multistage nanovectors based on mesoporous silicon have been extensively studied for drug delivery, thermal heating, and improved diagnostic imaging. Here, the short- and long-term changes occurring in human cells upon the internalization of mesoporous silicon nanovectors (MSV) are analyzed. Using qualitative and quantitative techniques as well as in vitro and in vivo biochemical, cellular, and functional assays, it is demonstrated that MSV do not cause any significant acute or chronic effects on cells and tissues. In vitro cell toxicity and viability are analyzed, as well as the maintenance of cell phase cycling and the architecture upon the internalization of MSV. In addition, it is evaluated whether MSV produce any pro-inflammatory responses and its biocompatibility in vivo is studied. The biodistribution of MSV is followed using longitudinal in vivo imaging and organ accumulation is assessed using quantitative elemental and fluorescent techniques. Finally, a thorough pathological analysis of collected tissues demonstrates a mild transient systemic response in the liver that dissipates upon the clearance of particles. It is proposed that future endeavors aimed at understanding the toxicology of naked drug carriers should be designed to address their impact using in vitro and in vivo short- and long-term evaluations of systemic response.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.