Evidence map›Paper›PMID 23255402›Full record

ReviewPediatric blood & cancer2013

Children's Oncology Group's 2013 blueprint for research: stem cell transplantation.

Stephan A Grupp, Christopher C Dvorak, Michael L Nieder, John E Levine, Donna A Wall, Bryan Langholz, Michael A Pulsipher, COG Stem Cell Transplant Scientific Committee

Erratum issuedOpen access · greenAbstract readReview
In one paragraph

Review in Pediatric blood & cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Challenges and opportunities for international cooperative studies in pediatric hematopoeitic cell transplantation: priorities of the Westhafen Intercontinental Group.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2013
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 2 countries.

Stephan A GruppChildren's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104-4318, USA. grupp@email.chop.edu
Christopher C Dvorak
Michael L Nieder
John E Levine
Donna A Wall
Bryan Langholz
Michael A Pulsipher
COG Stem Cell Transplant Scientific Committee
Children's Hospital of Philadelphia · USChildren's Oncology Group · USMoffitt Cancer Center · USUniversity of California, San Francisco · USUniversity of Manitoba · CAUniversity of Michigan–Ann Arbor · USUniversity of Utah · US

Funding

COG FOREIGN ACCRUALU10CA098543 · NCI · NATIONAL CHILDHOOD CANCER FOUNDATION · PI ADAMSON, PETER C. · 2003 to 2013
$335.5M
Children's Oncology Group Statistics &Data Center GrantU10CA098413 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ANDERSON, JAMES R · 2003 to 2013
$67.5M
Community Clinical Oncology Program Research BaseU10CA095861 · NCI · NATIONAL CHILDHOOD CANCER FOUNDATION · PI POLLOCK, BRAD H · 2002 to 2013
$19.5M
Support for Human Specimen Banking in NCI-Supported Cancer Clinical TrialsU24CA114766 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI RAMIREZ MILAN, NILSA DEL CARMEN · 2005 to 2014
$14.5M
USE OF mTOR INHIBITORS IN B CELL LEUKEMIAR01CA102646 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI GRUPP, STEPHAN A. · 2005 to 2009
$1.6M
Determinants of Relapse Risk After BMT for ALLR01CA116660 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI GRUPP, STEPHAN A. · 2007 to 2011
$1.5M
NCI NIH HHS R01 CA102646NCI NIH HHS R01CA102646NCI NIH HHS R01 CA1116660NCI NIH HHS R01 CA116660NCI NIH HHS U10 CA095861NCI NIH HHS U10 CA098413NCI NIH HHS U10 CA098543NCI NIH HHS U10 CA95861NCI NIH HHS U10CA98413NCI NIH HHS U10 CA98543NCI NIH HHS U24 CA114766
6 · The paper itself

Abstract

The role of SCT in pediatric oncology has continued to evolve with the introduction of new therapeutic agents and immunological insights into cancer. COG has focused its efforts on the study of hematopoietic stem cell transplantation in the treatment of pediatric malignancies in several major multi-institutional Phase II and Phase III studies. These studies include addressing the impact of allogenicity in ALL (ASCT0431), and establishing autologous stem cell transplant as the standard of care in neuroblastoma. Reducing transplant-associated toxicity was addressed in the ASCT0521 study, where the TNFα inhibitor etanercept was tested for the treatment of idiopathic pneumonia syndrome. Impact of cell dose was explored in the single versus tandem umbilical cord blood study CTN-0501, in close collaboration with the BMT-CTN.

Indexed as

Clinical Trials as TopicHematopoietic Stem Cell TransplantationChildHumansNeoplasmsResearch

Identifiers

PMID23255402
PMCPMC4064788
OpenAlexW2022374489

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.