ArticlePediatric blood & cancer2013
High rates of recurrent biliary tract obstruction in children with sickle cell disease.
Article in Pediatric blood & cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Acute Pancreatitis in Individuals with Sickle Cell Disease: A Systematic Review.Journal of clinical medicine · 2024Review
- Recurrent acute pancreatitis in an adult female with sickle cell disease: A case report.Annals of medicine and surgery (2012) · 2023Article
- Correlates of gallbladder stones among patients with sickle cell disease: A meta-analysis.JGH open : an open access journal of gastroenterology and hepatology · 2021Review
- Management of liver complications in sickle cell disease.Hematology. American Society of Hematology. Education Program · 2019Review
- Abdominal pain in a patient with sickle cell disease with multiple complications.Turk pediatri arsivi · 2019Article
- Choledocholithiases in a child with Hemoglobin Evans [alpha2 62(E11) Val→Met].Clinical case reports · 2016Article
- Implications of radiologic-pathologic correlation for gallbladder disease in children and young adults with sickle cell disease.Emergency radiology · 2015Article
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Authors and funding
3 authors at 2 institutions in 1 country.
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Abstract
backgroundIndividuals with sickle cell disease (SCD) have an increased risk of cholelithiasis from bilirubin stones. Symptomatic biliary tract disease (BTD) includes acute and chronic cholecystitis, obstruction of the common bile duct (CBD), cholangitis, and gallstone pancreatitis. Cholecystectomy is the main treatment strategy for symptomatic patients; however, the prevalence of recurrent BTD following cholecystectomy has not been systematically evaluated. We conducted a retrospective cohort study to describe the recurrence of BTD after cholecystectomy and characterize risk factors for recurrent disease. PROCEDURE: We identified patients <22 years of age who presented to the Johns Hopkins Children Center with symptomatic BTD from July 1993 to June 2008.
resultsWe identified 56 patients with a total of 76 episodes of symptomatic BTD (median age at first event 15.9, range 4.6-21.5 years). Eleven of the 56 patients (19.6%) had at least one episode of recurrent symptomatic BTD (median follow-up of 5.3 years). Baseline characteristics were similar between the patients with a single episode of BTD and those with recurrent BTD.
conclusionsThese results demonstrate that recurrent BTD is a frequent complication of SCD (20% by age 4 years) and often presents as CBD obstruction by stone, despite cholecystectomy. In our cohort, recurrence was not associated with age at first episode, baseline total bilirubin, gender, or genotype of SCD.
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