ArticleEMBO molecular medicine2013
Skin-draining lymph node priming is sufficient to induce sterile immunity against pre-erythrocytic malaria.
Article in EMBO molecular medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 36 citations in OpenAlex.
- Intradermal immunization with Plasmodium berghei late-arresting genetically attenuated sporozoites induces PD-L1 expression on regulatory macrophages and dendritic cells.Scientific reports · 2025Article
- Early Activation of Lung CD8Pathogens & immunity · 2025Article
- CD8Frontiers in immunology · 2024Review
- Innate immunity to malaria: The good, the bad and the unknown.Frontiers in immunology · 2022Review
- Diversify and Conquer: The Vaccine Escapism ofMicroorganisms · 2020Review
- Plasmodium sporozoites induce regulatory macrophages.PLoS pathogens · 2020Article
- Potential and Limitations of Cross-Protective Vaccine against Malaria by Blood-Stage Naturally Attenuated Parasite.Vaccines · 2020Article
- Rodents as Hosts of Pathogens and Related Zoonotic Disease Risk.Pathogens (Basel, Switzerland) · 2020Article
- Parasite load stemming from immunization route determines the duration of liver-stage immunity.Parasite immunology · 2019Article
- Vaccination With Sporozoites: Models and Correlates of Protection.Frontiers in immunology · 2019Review
- Intradermal delivery of a fractional dose of influenza H7N9 split vaccine elicits protective immunity in mice and rats.Human vaccines & immunotherapeutics · 2018Article
- The Threshold of Protection from Liver-Stage Malaria Relies on a Fine Balance between the Number of Infected Hepatocytes and Effector CD8Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Protozoan Parasites and Type I IFNs.Frontiers in immunology · 2017Review
- Protective immunity to liver-stage malaria.Clinical & translational immunology · 2016Review
- Skin scarification with Plasmodium falciparum peptide vaccine using synthetic TLR agonists as adjuvants elicits malaria sporozoite neutralizing immunity.Scientific reports · 2016Article
- Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites.Journal of visualized experiments : JoVE · 2016Article
- Colocalization of a CD1d-Binding Glycolipid with a Radiation-Attenuated Sporozoite Vaccine in Lymph Node-Resident Dendritic Cells for a Robust Adjuvant Effect.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Active migration and passive transport of malaria parasites.Trends in parasitology · 2015Review
- From the draining lymph node to the liver: the induction and effector mechanisms of malaria-specific CD8+ T cells.Seminars in immunopathology · 2015Review
- Lymph-node resident CD8α+ dendritic cells capture antigens from migratory malaria sporozoites and induce CD8+ T cell responses.PLoS pathogens · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
The Plasmodium-infected hepatocyte has been considered necessary to prime the immune responses leading to sterile protection after vaccination with attenuated sporozoites. However, it has recently been demonstrated that priming also occurs in the skin. We wished to establish if sterile protection could be obtained in the absence of priming by infected hepatocytes. To this end, we developed a subcutaneous (s.c.) immunization protocol where few, possibly none, of the immunizing irradiated Plasmodium yoelii sporozoites infect hepatocytes, and also used CD81-deficient mice non-permissive to productive hepatocyte infections. We then compared and contrasted the patterns of priming with those obtained by intradermal immunization, where priming occurs in the liver. Using sterile immunity as a primary read-out, we exploited an inhibitor of T-cell migration, transgenic mice with conditional depletion of dendritic cells and adoptive transfers of draining lymph node-derived T cells, to provide evidence that responses leading to sterile immunity can be primed in the skin-draining lymph nodes with little, if any, contribution from the infected hepatocyte.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.