ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2013
Positron emission tomography in the assessment of left ventricular function in healthy rats: a comparison of four imaging methods.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
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- Assessment of left and right ventricular functional parameters using dynamic dual-tracer [Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Comparison of transient and permanent LAD ligation in mice using 18F-FDG PET imaging.Annals of nuclear medicine · 2022Article
- Left ventricle function assessment using gated first-passJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Cardiac 18F-FDG Positron Emission Tomography: An Accurate Tool to MonitorFrontiers in cardiovascular medicine · 2021Article
- The Number of Frames on ECG-GatedMolecular imaging · 2021Article
- Left Ventricular Diastolic Dysfunction in a Rat Model of Diabetic Cardiomyopathy using ECG-gatedScientific reports · 2018Article
- Feasibility of biventricular volume and function assessment using first-pass gatedEJNMMI research · 2018Article
- Derivation of a respiration trigger signal in small animal list-mode PET based on respiration-induced variations of the ECG signal.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Synthesis of fluorine-18 radio-labeled serum albumins for PET blood pool imaging.Nuclear medicine and biology · 2015Article
- In-vivo monitoring of erythropoietin treatment after myocardial infarction in mice with [⁶⁸Ga]Annexin A5 and [¹⁸F]FDG PET.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo measure left ventricular (LV) function parameters in heart of healthy rats by three different positron emission tomography (PET) imaging techniques and by magnetic resonance imaging (MRI).
methodsECG-gated microPET examinations were obtained in seven healthy rats with 2-deoxy-2-[(18)F]fluoro-D-glucose (FDG) for calculation of LV-function from the blood-pool phase of the dynamic recording (FDGBP), and also from the later myocardial uptake (FDGMyo). On subsequent days, we re-measured LV-function using the novel blood-pool tracer (68)Ga-albumin (AlbBP) and again by FDG (FDGMyo2) in one setting. Cine-MRI examination provided the reference standard measurement.
resultsThe mean LV ejection fractions (LVEF) were 56 ± 3 (FDGBP), 55 ± 3 (FDGMyo), 56 ± 3 (FDGMyo2), 57 ± 3 (AlbBP), and 57 ± 2 (MRI). There were good to excellent correlations found between the LVEF-values as compared to MRI reference standard for FDGBP (r = 0.71), FDGMyo (r = 0.86) and AlbBP (r = 0.88). Both of the blood-pool methods significantly overestimated the magnitudes of end-diastolic-volume and end-systolic-volume, whereas FDGMyo matched closely to the MRI reference standard. There was no significant bias for both blood-pool methods and a minor negative bias for FDGMyo regarding the LV ejection fraction (LVEF) when compared to cine-MRI results. There was no significant difference between the means of FDGMyo and FDGMyo2 (P = .50).
conclusionsRelative to reference standard MRI measurements of LVEF, there was excellent agreement between PET-based measurements, notably for the novel blood-pool tracer (68)Ga-albumin.
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