Evidence map›Paper›PMID 23255201›Full record

ArticleCurrent protocols in nucleic acid chemistry2012

Synthesis of a North-methanocarba-thymidine (N-MCT) analog.

Andrew Thompson, Victor E Marquez

Abstract read
In one paragraph

Article in Current protocols in nucleic acid chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Andrew ThompsonJ-Star Research, Inc., South Plainfield, New Jersey, USA.
Victor E Marquez

Funding

DIDEOXYNUCLEOSIDES AS POTENTIAL ANTI-AIDS DRUGSZ01BC006173 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MARQUEZ, VICTOR · 1996 to 2008
$635k
CYCLOPENTENYL NUCLEOSIDE ISOSTERES AS POTENTIAL ANTITUMOR AND ANTIVIRAL AGENTSZ01BC006174 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MARQUEZ, VICTOR · 1996 to 2008
$635k
Intramural NIH HHS Z01 BC006173Intramural NIH HHS Z01 BC006174
6 · The paper itself

Abstract

A detailed protocol for the synthesis of North-methanocarba-thymidine (N-MCT), a potent antiviral nucleoside with a restricted bicyclo[3.1.0]hexane pseudosugar conformation, is presented. The process is described in two parts. The first basic protocol deals with the synthesis of the carbobicyclic pseudosugar precursor that can be utilized in the syntheses of other bicyclo[3.1.0]hexane nucleosides with natural and non-natural nucleobases. The second basic protocol describes the specific construction of the thymine base in a linear fashion from the carbobicyclic intermediate.

Indexed as

Nucleic Acid ConformationAntiviral AgentsBridged Bicyclo CompoundsCarbasugarsHerpesvirus 2, HumanThymidineThymineAntiviral AgentsBridged Bicyclo CompoundsCarbasugarsThymidineThymine

Identifiers

PMID23255201
PMCPMC7477758

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.