ArticleCell cycle (Georgetown, Tex.)2013
Spermidine promotes mating and fertilization efficiency in model organisms.
Article in Cell cycle (Georgetown, Tex.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Spermidine reduces peri-implant inflammation and fibrosis to nurture osseointegration.Bioactive materials · 2026Article
- Spermidine supplementation and protein restriction protect from organismal and brain aging independently.Aging · 2025Article
- Separation of reproductive decline from lifespan extension during methionine restriction.Nature aging · 2024Article
- The effect of spermine on Tetranychus urticae-Cucumis sativus interaction.BMC plant biology · 2023Article
- Spermidine promotes fertility in aged female mice.Nature aging · 2023Article
- Polyamine metabolite spermidine rejuvenates oocyte quality by enhancing mitophagy during female reproductive aging.Nature aging · 2023Article
- Inhibition of Polyamine Catabolism Reduces Cellular Senescence.International journal of molecular sciences · 2023Article
- Gene transcriptional profiles in gonads of Bacillus taxa (Phasmida) with different cytological mechanisms of automictic parthenogenesis.Zoological letters · 2022Article
- Review
- Article
- Redox regulation & sperm function: A proteomic insight.The Indian journal of medical research · 2018Review
- Lifespan extension without fertility reduction following dietary addition of the autophagy activator Torin1 in Drosophila melanogaster.PloS one · 2018Article
- Review
- Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy.Cancer research · 2017Article
- Soft TCPTP Agonism-Novel Target to Rescue Airway Epithelial Integrity by Exogenous Spermidine.Frontiers in pharmacology · 2016Article
- Caloric restriction mimetics: towards a molecular definition.Nature reviews. Drug discovery · 2014Review
- Does dietary folic acid supplementation in mouse NTD models affect neural tube development or gamete preference at fertilization?BMC genetics · 2014Article
- Fertility and polarized cell growth depends on eIF5A for translation of polyproline-rich formins in Saccharomyces cerevisiae.Genetics · 2014Article
- Immunogenic calreticulin exposure occurs through a phylogenetically conserved stress pathway involving the chemokine CXCL8.Cell death and differentiation · 2014Article
- The cell death protease Kex1p is essential for hypochlorite-induced apoptosis in yeast.Cell cycle (Georgetown, Tex.) · 2013Article
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14 authors at 4 institutions in 6 countries.
Funding
Abstract
Spermidine is a naturally occurring polyamine involved in multiple biological processes, including DNA metabolism, autophagy and aging. Like other polyamines, spermidine is also indispensable for successful reproduction at several stages. However, a direct influence on the actual fertilization process, i.e., the fusion of an oocyte with a spermatocyte, remains uncertain. To explore this possibility, we established the mating process in the yeast Saccharomyces cerevisiae as a model for fertilization in higher eukaryotes. During human fertilization, the sperm capacitates and the acrosome reaction is necessary for penetration of the oocyte. Similarly, sexually active yeasts form a protrusion called "shmoo" as a prerequisite for mating. In this study, we demonstrate that pheromone-induced shmoo formation requires spermidine. In addition, we show that spermidine is essential for mating in yeast as well as for egg fertilization in the nematode Caenorhabditis elegans. In both cases, this occurs independently from autophagy. In synthesis, we identify spermidine as an important mating component in unicellular and multicellular model organisms, supporting an unprecedented evolutionary conservation of the mechanisms governing fertilization-related cellular fusion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.