Observational studyIndian journal of pediatrics2013
Evaluation of predictors of adverse outcome in febrile neutropenic episodes in pediatric oncology patients.
Observational study in Indian journal of pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Cathelicidin, but not vitamin D, is associated independently with sepsis in pediatric patients with cancer and febrile neutropenia.Molecular and clinical oncology · 2025Article
- Bacterial Isolates and Characteristics of Children With Febrile Neutropenia on Treatment for Cancer at a Tertiary Hospital in Western Kenya.JCO global oncology · 2024Article
- Identifying Risk Factors and Improving Preventive Strategies for Febrile Neutropenia in Children with Leukemia Receiving Ciprofloxacin ProphylaxisTurkish journal of haematology : official journal of Turkish Society of Haematology · 2023Article
- A randomized controlled trial to explore the safety and efficacy of irradiated buffy-coat granulocytes in pediatric patients with febrile neutropenia.American journal of blood research · 2023Article
- Update on Febrile Neutropenia in Pediatric Oncological Patients Undergoing Chemotherapy.Children (Basel, Switzerland) · 2021Review
- Risk stratification in children with cancer and febrile neutropenia: A national, prospective, multicentre validation of nine clinical decision rules.EClinicalMedicine · 2020Article
- Risk factors for bacteremia in children with febrile neutropeniaTurkish journal of medical sciences · 2019Article
- The Comparison of The Efficacy and Safety of Original and Biosimilar Filgrastim in Prevention of Chemotherapy-Induced Neutropenia in Children with Cancer.The Eurasian journal of medicine · 2019Article
- Prevalence and Predictors of Invasive Fungal Infections in Children with Persistent Febrile Neutropenia Treated for Acute Leukemia - A Prospective Study.Indian journal of pediatrics · 2018Observational
- Can complications in febrile neutropenia be predicted? Report from a developing country.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Article
- [Pathogens of infections in the induction period of childhood acute lymphoblastic leukemia and drug resistance of isolated strains].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017Article
- Use of Fungal Diagnostics and Therapy in Pediatric Cancer Patients in Resource-Limited Settings.Current clinical microbiology reports · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo identify predictors associated with adverse outcome in febrile neutropenic episodes among pediatric oncology patients between 1 and 18 y age, to ascertain the prevalence of invasive bacterial or fungal infection/mortality, to determine the common organisms causing invasive bacterial infection in children with febrile neutropenia and to evaluate their current antimicrobial sensitivity pattern.
methodsIt was an observational descriptive study conducted between February 2009 through July 2010. Febrile neutropenic episodes satisfying the inclusion criteria were enrolled. Relevant history was taken followed by a detailed clinical examination and laboratory examination. Logistic Regression analysis was used to identify significant predictors of adverse outcome in febrile neutropenic episodes.
resultsOut of the 155 febrile neutropenic episodes studied, adverse outcome occurred in 53(34 %) of the episodes. History of three or more previous episodes of febrile neutropenia, child being already on oral antibiotics and Chest Radiograph abnormality at presentation were found to be significantly associated with adverse outcome on multivariate logistic regression analysis. Documented invasive bacterial and fungal infection was seen in 27.8 % and 14.2 % episodes. Mortality occurred in 8 (5 %) of episodes. Gram negative bacterial infections were more common. Most common bacteria isolated was Escherichia coli and the commonest gram positive organism isolated was Staphylococcus aureus (MSSA).
conclusionsOn multivariate analysis, the variables found to be significantly associated with adverse outcome in febrile neutropenic episodes were three or more previous episodes of febrile neutropenia, child being already on oral antibiotics and Chest Radioraph abnormality at presentation.
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