ArticleCancer biology & therapy2013
Statins impair glucose uptake in tumor cells.
Article in Cancer biology & therapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Metabolic Signature ofJournal of personalized medicine · 2025Review
- CAV1 - GLUT3 signaling is important for cellular energy and can be targeted by Atorvastatin in Non-Small Cell Lung Cancer.Theranostics · 2019Article
- Statin and Bisphosphonate Induce Starvation in Fast-Growing Cancer Cell Lines.International journal of molecular sciences · 2017Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Statins play a pivotal role in lowering the blood cholesterol level, which is critical for patients with hypercholesterolemia. In addition to its benefits in cardiovascular protection, statins have been found to be useful in several other clinical conditions, including cancer. In a recent report that appeared in Neoplasia, Malenda et al., have demonstrated that statins inhibit glucose uptake in cancer cells. Using multiple statins and glucose analogs ( ( 18) FDG and 6-NBDG) they showed that inhibition of cholesterol synthesis underlies the blockade of glucose uptake in several cancer cell lines. Further, based on an exploratory clinical study, they also showed that diagnostic PET-CT imaging in patients treated for hypercholesterolemia was affected due to statin-mediated inhibition of glucose uptake. As the finding is based on the data from a single patient (out of four), it seems that (1) the need for a large cohort study and (2) the detailed characterization of the molecular mechanisms underlying such biological effects would be justified.
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Registered trials
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