ArticleThe Journal of comparative neurology2013
Distribution and intrinsic membrane properties of basal forebrain GABAergic and parvalbumin neurons in the mouse.
Article in The Journal of comparative neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
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Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Connectivity and Functionality of the Globus Pallidus Externa Under Normal Conditions and Parkinson's Disease.Frontiers in neural circuits · 2021Pooled it
- Deep brain stimulation of the nucleus basalis of Meynert in neurodegenerative diseases with cognitive impairment: An update on evidence and mechanisms.Neural regeneration research · 2026Article
- Article
- Calretinin-Expressing Neurons in the Basal Forebrain Specifically Contact Granule Cells in the Olfactory Bulb and Modulate Odor Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Parvalbumin-expressing basal forebrain neurons mediate learning from negative experience.Nature communications · 2024Article
- Neuronal PAS domain 1 identifies a major subpopulation of wakefulness-promoting GABAergic neurons in the basal forebrain.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Basal forebrain parvalbumin neurons modulate vigilant attention and rescue deficits produced by sleep deprivation.Journal of sleep research · 2024Article
- Hyperactive mTORC1 in striatum dysregulates dopamine receptor expression and odor preference behavior.Frontiers in neuroscience · 2024Article
- Cognitive Aging and the Primate Basal Forebrain Revisited: Disproportionate GABAergic Vulnerability Revealed.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The medial septum controls hippocampal supra-theta oscillations.Nature communications · 2023Article
- Facilitation of Behavioral and Cortical Emergence from Isoflurane Anesthesia by GABAergic Neurons in Basal Forebrain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Role of the locus coeruleus and basal forebrain in arousal and attention.Brain research bulletin · 2022Review
- Dynamic subcortical modulators of human default mode network function.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- GABAergic and Glutamatergic Phenotypes of Neurons Expressing Calcium-Binding Proteins in the Preoptic Area of the Guinea Pig.International journal of molecular sciences · 2022Article
- Outcome-Locked Cholinergic Signaling Suppresses Prefrontal Encoding of Stimulus Associations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Optogenetics: implications for Alzheimer's disease research and therapy.Molecular brain · 2022Review
- Neural Substrates for the Regulation of Sleep and General Anesthesia.Current neuropharmacology · 2022Review
- Effect of basal forebrain somatostatin and parvalbumin neurons in propofol and isoflurane anesthesia.CNS neuroscience & therapeutics · 2021Article
- Optogenetic manipulation of an ascending arousal system tunes cortical broadband gamma power and reveals functional deficits relevant to schizophrenia.Molecular psychiatry · 2021Article
- Characterization of basal forebrain glutamate neurons suggests a role in control of arousal and avoidance behavior.Brain structure & function · 2021Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
The basal forebrain (BF) strongly regulates cortical activation, sleep homeostasis, and attention. Many BF neurons involved in these processes are GABAergic, including a subpopulation of projection neurons containing the calcium-binding protein, parvalbumin (PV). However, technical difficulties in identification have prevented a precise mapping of the distribution of GABAergic and GABA/PV+ neurons in the mouse or a determination of their intrinsic membrane properties. Here we used mice expressing fluorescent proteins in GABAergic (GAD67-GFP knock-in mice) or PV+ neurons (PV-Tomato mice) to study these neurons. Immunohistochemical staining for GABA in GAD67-GFP mice confirmed that GFP selectively labeled BF GABAergic neurons. GFP+ neurons and fibers were distributed throughout the BF, with the highest density in the magnocellular preoptic area (MCPO). Immunohistochemistry for PV indicated that the majority of PV+ neurons in the BF were large (>20 μm) or medium-sized (15-20 μm) GFP+ neurons. Most medium and large-sized BF GFP+ neurons, including those retrogradely labeled from the neocortex, were fast-firing and spontaneously active in vitro. They exhibited prominent hyperpolarization-activated inward currents and subthreshold "spikelets," suggestive of electrical coupling. PV+ neurons recorded in PV-Tomato mice had similar properties but had significantly narrower action potentials and a higher maximal firing frequency. Another population of smaller GFP+ neurons had properties similar to striatal projection neurons. The fast firing and electrical coupling of BF GABA/PV+ neurons, together with their projections to cortical interneurons and the thalamic reticular nucleus, suggest a strong and synchronous control of the neocortical fast rhythms typical of wakefulness and REM sleep.
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